Most Read Articles
22 Nov 2020
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

4 days ago
Vitamin D deficiency may be a contributing factor to the mortality rate among patients with the novel coronavirus disease (COVID-19), reports a new study.
Pearl Toh, 2 days ago
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.

Stress, anxiety, depression greater in treatment-naïve women with breast cancer

19 Oct 2020

Treatment-naïve women with breast cancer are at a greater risk of perceived stress and of symptoms of anxiety and depression, finds a new study.

The study included 360 participants (mean age, 40.63±8.62) who were grouped into three, each comprising 120 patients: treatment-naïve breast cancer patients, benign disease controls, and health controls. The Perceived Stress Scale-4 items (PSS-4), Patient Health Questionnaire (PHQ-9), and Generalized Anxiety Disorder Scale (GAD-7) were used to assess psychological outcomes.

Perceived stress was significantly different among the breast cancer, benign control, and healthy control groups (5.95±2.51 vs 5.28±2.58 vs 4.33±2.31, respectively; p<0.001), as were anxiety (p=0.011) and depression (p<0.001). Spearman correlation analysis found that stress significantly interacted with both depression and anxiety (p<0.001 for both).

Multivariable regression analysis showed that women who were treatment-naïve were at a significantly greater risk of perceived stress than comparators with benign disease (B, –0.71, 95 percent confidence interval [CI], –1.34 to –0.07; p=0.029) and heathy controls (B, –1.58, 95 percent CI, –2.21 to –0.95; p<0.001).

Anxiety was also more likely to develop in patients than in benign-disease and healthy controls, though this effect was attenuated after adjusting for perceived stress. The risk of depression was only greater relative to healthy controls, but was independent of perceived stress.

Mediation analysis confirmed that stress had both a relative direct and indirect effect on depression, while only its relative indirect effect on anxiety was significant.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
22 Nov 2020
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

4 days ago
Vitamin D deficiency may be a contributing factor to the mortality rate among patients with the novel coronavirus disease (COVID-19), reports a new study.
Pearl Toh, 2 days ago
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.