Most Read Articles
Roshini Claire Anthony, 11 Sep 2019

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Elvira Manzano, 2 days ago

The US Preventive Services Task Force (USPSTF), in an update of its 2013 recommendations, called on clinicians to offer risk-reducing medications to women who are at increased risk for breast cancer but at low risk for adverse effects.

Pearl Toh, 3 days ago
The use of SGLT-2* inhibitors was not associated with a higher risk of severe or nonsevere urinary tract infections (UTIs) in patients with type 2 diabetes (T2D) compared with DPP**-4 inhibitors or GLP-1*** receptor agonists, a population-based cohort study shows.
14 Sep 2019
In type 2 diabetes patients taking sulfonylureas, hypoglycaemia duration is longer at night and is inversely correlated with the level of glycated haemoglobin (HbA1c), a new study reports.

Stereotactic radiotherapy a viable treatment option for solitary kidney tumours

31 May 2019

Stereotactic ablative radiotherapy has shown its capability as a treatment option in patients with renal cell carcinoma in a solitary kidney, achieving excellent oncologic outcomes as well as having an acceptable impact on renal function, according to an analysis of the IROCK (International Radiosurgery Oncology Consortium for Kidney) database.

Eighty-one patients (mean age, 67.3 years; median tumour diameter, 3.7 cm, IQR, 2.5–4.3; 37 percent of tumours were 4cm) with a solitary kidney underwent stereotactic ablative radiotherapy, of whom 97.5 percent had good performance status, including ECOG (Eastern Cooperative Oncology Group) 0-1 or KPS (Karnofsky Performance Status) 70 percent.

Patients (n=138) in the bilateral kidney cohort had larger tumours and were older (p<0.001), with a lower baseline estimated glomerular filtration rate (eGFR; p=0.024).

After stereotactic radiotherapy in the solitary kidney cohort, patients had a mean estimated eGFR decrease of –5.8±10.8 ml per minute (–9 percent), and none of them required dialysis. Furthermore, a tumour size of 4 cm correlated with an eGFR decrease of 15 ml per minute (odds ratio, 4.2; p=0.029).

The rate of local control at 2 years was 98.0 percent, while progression-free, cancer-specific and overall survival rates were 77.5 percent, 98.2 percent and 81.5 percent, respectively. No significant between-group difference was observed in renal function or oncologic outcomes (p>0.05).

This study pooled individual patient data from nine IROCK institutions in Germany Australia, Japan, Canada and US, with a median follow-up of 2.6 years. The authors compared baseline characteristics and outcomes between the solitary and bilateral kidney cohorts. Logistic regression modeling was used to assess the predictors of renal function after stereotactic radiotherapy.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Roshini Claire Anthony, 11 Sep 2019

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Elvira Manzano, 2 days ago

The US Preventive Services Task Force (USPSTF), in an update of its 2013 recommendations, called on clinicians to offer risk-reducing medications to women who are at increased risk for breast cancer but at low risk for adverse effects.

Pearl Toh, 3 days ago
The use of SGLT-2* inhibitors was not associated with a higher risk of severe or nonsevere urinary tract infections (UTIs) in patients with type 2 diabetes (T2D) compared with DPP**-4 inhibitors or GLP-1*** receptor agonists, a population-based cohort study shows.
14 Sep 2019
In type 2 diabetes patients taking sulfonylureas, hypoglycaemia duration is longer at night and is inversely correlated with the level of glycated haemoglobin (HbA1c), a new study reports.