Most Read Articles
Stephen Padilla, 22 Jul 2019
Zinc supplementation significantly lowers key glycaemic indicators, particularly fasting glucose (FG) in individuals with diabetes and in those who received an inorganic supplement, results of a systematic review and meta-analysis have shown.
Elaine Soliven, 15 Oct 2020

Higher levels of exercise appear to be associated with a lower risk of all-cause mortality in adults with type 2 diabetes (T2D) compared with no exercise at all, according to a study presented at EASD 2020.

Elvira Manzano, 07 Oct 2020
Exendin-4 imaging targeting GLP-1* receptor (GLP-1R) ably detects residual, dysfunctional pancreatic beta cells in individuals with long-standing type 1 diabetes (T1D), according to a study presented at EASD 2020. This breakthrough brings research closer to the possibility of restoring insulin-producing cells depleted in T1D.
Elaine Soliven, 3 days ago
Ultra rapid lispro (URLi) was noninferior to lispro in reducing HbA1c levels in adults with type 1 diabetes (T1D), according to the PRONTO-Pump-2* study presented at EASD 2020.

Stem cell therapy shows promise for T2DM

06 Oct 2020

While not a cure, mesenchymal stem cell therapy is able to effectively improve the control of type 2 diabetes mellitus (T2DM), reports a new meta-analysis.

From the databases of PubMed, Web of Science, Central, and Scopus, researchers identified 57 studies for analysis. Only those that were randomized controlled trials were eligible, and from each study, information about C-peptide and glycated haemoglobin (HbA1c) levels, as well as insulin dose, were collected.

Three studies looked at the effect of mesenchymal stem cells on C-peptide levels and showed no considerable heterogeneity among them (p=0.109). However, cell therapy did not seem to exert any significant impact on C-peptide levels in T2DM patients (standardized mean difference [SMD], 0.2, 95 percent confidence interval [CI], –0.61 to 1.00).

On the other hand, pooled analysis of seven studies revealed that mesenchymal stem cell therapy significantly reduced HbA1c concentrations in patients (SMD, –1.45, 95 percent CI, –2.10 to –0.79). The evidence for this combined analysis showed significant heterogeneity (p=0.000).

The same was true for insulin dosage, which was significantly decreased following cell therapy (SMD, –1.40, 95 percent CI, –2.88 to 0.09), though with high heterogeneity of evidence (p=0.000).

“Based on present review and other studies, cell therapy is not a cure but is a clinically safe method for ameliorating diabetes mellitus. Broad investigations to study the precise effect of cell therapy on DM patients with more experimental details of humoral factors, cellular and molecular analysis, could be of great benefit in better conceiving this method in treatment of diabetes, especially T2DM,” researchers said.

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Most Read Articles
Stephen Padilla, 22 Jul 2019
Zinc supplementation significantly lowers key glycaemic indicators, particularly fasting glucose (FG) in individuals with diabetes and in those who received an inorganic supplement, results of a systematic review and meta-analysis have shown.
Elaine Soliven, 15 Oct 2020

Higher levels of exercise appear to be associated with a lower risk of all-cause mortality in adults with type 2 diabetes (T2D) compared with no exercise at all, according to a study presented at EASD 2020.

Elvira Manzano, 07 Oct 2020
Exendin-4 imaging targeting GLP-1* receptor (GLP-1R) ably detects residual, dysfunctional pancreatic beta cells in individuals with long-standing type 1 diabetes (T1D), according to a study presented at EASD 2020. This breakthrough brings research closer to the possibility of restoring insulin-producing cells depleted in T1D.
Elaine Soliven, 3 days ago
Ultra rapid lispro (URLi) was noninferior to lispro in reducing HbA1c levels in adults with type 1 diabetes (T1D), according to the PRONTO-Pump-2* study presented at EASD 2020.