Most Read Articles
Pearl Toh, 3 days ago
Not only does the CGRP* inhibitor galcanezumab show sustained efficacy in migraine patients, long-term treatment does not come with excess cardiovascular (CV) risk, according to studies presented at the AAN 2021 Annual Meeting.
01 Apr 2021
Migraine and headache are common ailments of people living in the modern era. Dr Jon Marshall of The Singapore Headache and Migraine Clinic shares his insights with Pearl Toh on how to manage migraine and headache using non-pharmaceutical strategies, with a focus on the manual medicine approach.
Tristan Manalac, 5 days ago
Visceral fat area is the strongest indicator of mobility disability among obese, community-dwelling, older adults, according to a recent Singapore study.
3 days ago
In a webinar held on 27 March 2021, paediatric endocrinology nurses Karen Blair, Kate Davies, and Siti Zarina Yaakop shared insights and clinical experience based on their frontline roles in caring for patients with central precocious puberty (CPP) and supporting their family members.

Stem cell injections deliver benefits on OA-related structural outcomes

24 Apr 2021
Stem cell therapy may have some promising applications, but patients should be wary of undergoing questionable medical procedures by unscrupulous for-profit clinics.

Intra-articular mesenchymal stem cell (MSC) injections on articular cartilage and subchondral bone result in improved osteoarthritis (OA)-related structural outcomes, according to a systematic review of early-phase clinical trials.

The investigators searched Ovid Medline and Embase from inception to April 2020 using MeSH terms and keywords. Independent reviewers extracted data and evaluated methodological quality. Qualitative evidence synthesis was carried out due to the heterogeneity of interventions and outcome measures.

Thirteen randomized controlled trials (phase I or II) were identified, of which 10 included OA populations and three involved populations at risk of OA. Risk of bias was high in one study, moderate in three, and low in nine.

Seven studies used allogeneic MSCs (four bone marrow, one umbilical cord, one placenta, and one adipose tissue), while six used autologous MSCs (three adipose tissue, two bone marrow, and one peripheral blood).

Ten of the 11 studies examining cartilage outcomes found MSCs to be advantageous on cartilage volume, morphology, quality, regeneration, and repair, as assessed by magnetic resonance imaging, arthroscopy, or histology. The evidence for subchondral bone was consistent in all three studies on populations at risk of OA, demonstrating beneficial effects.

In addition, 16 unpublished, eligible trials were identified through trial registries search, including eight with actual or estimated completion dates before 2016.

“Due to the heterogeneity of MSCs, modest sample sizes, methodological limitations, and potential for publication bias, further work is needed before this therapy is recommended in the management of OA,” the investigators said.

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Most Read Articles
Pearl Toh, 3 days ago
Not only does the CGRP* inhibitor galcanezumab show sustained efficacy in migraine patients, long-term treatment does not come with excess cardiovascular (CV) risk, according to studies presented at the AAN 2021 Annual Meeting.
01 Apr 2021
Migraine and headache are common ailments of people living in the modern era. Dr Jon Marshall of The Singapore Headache and Migraine Clinic shares his insights with Pearl Toh on how to manage migraine and headache using non-pharmaceutical strategies, with a focus on the manual medicine approach.
Tristan Manalac, 5 days ago
Visceral fat area is the strongest indicator of mobility disability among obese, community-dwelling, older adults, according to a recent Singapore study.
3 days ago
In a webinar held on 27 March 2021, paediatric endocrinology nurses Karen Blair, Kate Davies, and Siti Zarina Yaakop shared insights and clinical experience based on their frontline roles in caring for patients with central precocious puberty (CPP) and supporting their family members.