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Tristan Manalac, Yesterday
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Steep haemoglobin drops in women with postpartum haemorrhage

23 Dec 2020
It was speculated that the family’s wish for a second child in a short period of time might be the reason why they allegedly refused permission for a C-section delivery.

Women with postpartum haemorrhage (PPH) experience greater haemoglobin (Hb) reduction than those without PPH, a recent study has found.

“Hb levels should be monitored for at least 48 hours after delivery to detect anaemia requiring iron sucrose treatment and/or blood transfusion,” the researchers said.

The study included 419 women who had complete blood counts taken before and after delivery. Sixty-four percent (n=248) of the participants had bleeding-related complications, and were designated as the PPH group; the remaining 36 percent (n=151) were set as controls. In the PPH group, 158 had occult PPH, and 110 had overt PPH.

In the immediate postpartum period, women with PPH experienced a significantly greater drop in mean Hb than controls (2.4±1.6 vs 0.9±1.0 g/dL; p<0.0001). Haematocrit (HCT) showed the same trend (7±4 percent vs 3±3 percent; p<0.0001).

Moreover, Hb reductions of ≥2 g/dL (odds ratio [OR], 5.6, 95 percent confidence interval [CI], 3.1–10.2) and ≥3 g/dL (OR, 8.6, 95 percent CI, 3.3–22.3) were significantly more likely to occur in participants with PPH.

Sub-analysis according to the type of PPH showed that Hb reductions were greater for overt than occult PPH patients (3.0±1.6 vs 2.0±1.4 g/dL). Similarly, HCT decreases in women with occult PPH fell in between controls and overt PPH patients. Nevertheless, women with either PPH subtype experienced significantly greater reductions in both markers (p<0.0001 for both).

In all groups, the researchers observed that the rate of Hb decline peaked 6–12 hours postpartum and plateaued at 24–48 hours.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Tristan Manalac, Yesterday
While antibody titres against SARS-CoV-2 wane with time, the immune system is capable of producing memory B-cells that can last for at least 6 months after infection, suggesting that the body will be able to protect itself in the case of re-exposure, according to a new study.
Jairia Dela Cruz, 5 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.