Most Read Articles
Tristan Manalac, 11 Jul 2018
Gestational exposure to grain products fortified with folic acid appears to be linked to a lower risk of psychosis in offspring, according to a recent study.
Pearl Toh, 10 Jul 2018
A dual-hormone artificial pancreas (DAP) with a rapid delivery of insulin and pramlintide in a fixed ratio improves glycaemic control and reduces glucose variability in adults with type 1 diabetes (T1D) compared with first-generation artificial pancreas delivering insulin alone, according to a study presented at ADA 2018.
4 days ago
Chocolate consumption is not associated with risk of coronary heart disease (CHD), stroke or both combined in postmenopausal women free of pre-existing major chronic disease, a study suggests.
Pearl Toh, 5 days ago
More intensive lowering of LDL-C levels was associated with a progressively greater survival benefit than less intensive approach, when the baseline LDL-C levels were ≥100 mg/dL, reveals a meta-analysis of 34 randomized trials.

Statins protect against hepatocellular carcinoma

10 Mar 2018
Statin, a blood cholesterol-lowering medicine, reduces sharply in blood cholesterol levels among ACS patients.

High-risk patients may benefit from a protective effect of statins against hepatocellular carcinoma (HCC), a recent study suggests. This effect appears to be greater in patients with diabetes mellitus (DM) or liver cirrhosis (LC).

Researchers drew data from the 2002–2013 National Health Insurance Service Physical Health Examination Cohort in the Republic of Korea. Multivariable conditional logistic regression analysis was performed to determine the association of HCC with statin use.

The use of statins was significantly less common in 1,642 HCC patients than in 8,210 age-, sex- and index date-matched controls, including simvastatin (odds ratio [OR], 0.44; 95 percent CI, 0.33–0.58), atorvastatin (OR, 0.49; 0.37–0.65), lovastatin (OR, 0.34; 0.16–0.73), rosuvastatin (OR, 0.56; 0.31–0.98) and pitavastatin (OR, 0.31; 0.13–0.77).

There was a significant association between statin use and a lower risk of HCC incidence relative to nonuse (adjusted OR, 0.44; 0.33–0.58).

Cumulative doses of statin also appeared to yield a trend of risk reduction. The corresponding adjusted ORs for <180, 180–365, 365–720 and 720 cumulative defined daily doses of statin use were 0.45 (0.32–0.64), 0.56 (0.31–1.00), 0.41 (0.22–0.76) and 0.30 (0.14–0.63).

The inhibitory effect of statins on HCC was stronger in patients with DM (adjusted OR, 0.28; 0.17–0.46) and LC (adjusted OR, 0.39; 0.26–0.70) relative to statin users without the said conditions (adjusted OR for DM, 0.53; 0.39–0.73; adjusted OR for LC, 0.42; 0.32–0.57).

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Most Read Articles
Tristan Manalac, 11 Jul 2018
Gestational exposure to grain products fortified with folic acid appears to be linked to a lower risk of psychosis in offspring, according to a recent study.
Pearl Toh, 10 Jul 2018
A dual-hormone artificial pancreas (DAP) with a rapid delivery of insulin and pramlintide in a fixed ratio improves glycaemic control and reduces glucose variability in adults with type 1 diabetes (T1D) compared with first-generation artificial pancreas delivering insulin alone, according to a study presented at ADA 2018.
4 days ago
Chocolate consumption is not associated with risk of coronary heart disease (CHD), stroke or both combined in postmenopausal women free of pre-existing major chronic disease, a study suggests.
Pearl Toh, 5 days ago
More intensive lowering of LDL-C levels was associated with a progressively greater survival benefit than less intensive approach, when the baseline LDL-C levels were ≥100 mg/dL, reveals a meta-analysis of 34 randomized trials.