Most Read Articles
18 Apr 2018
Higher intake levels of coffee appear to be associated with reduced risk of developing chronic kidney disease, according to data from the Atherosclerosis Risk in Communities Study.
Jairia Dela Cruz, 20 Apr 2018
Infants delivered via caesarean section may be at increased risk of developing acute lymphoblastic leukaemia, according to a US study. Altered microbiota colonization is a possible explanation for this risk, although clear biological mechanisms have yet to be established.
6 days ago
Treatment with danegaptide does not improve myocardial salvage in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention, according to the results of a phase II study.
Pearl Toh, 4 days ago
Tai Chi may be equivalent to pulmonary rehabilitation (PR) in improving health status of patients with chronic obstructive pulmonary disease (COPD), a recent study shows.

Statins protect against hepatocellular carcinoma

10 Mar 2018
Statin, a blood cholesterol-lowering medicine, reduces sharply in blood cholesterol levels among ACS patients.

High-risk patients may benefit from a protective effect of statins against hepatocellular carcinoma (HCC), a recent study suggests. This effect appears to be greater in patients with diabetes mellitus (DM) or liver cirrhosis (LC).

Researchers drew data from the 2002–2013 National Health Insurance Service Physical Health Examination Cohort in the Republic of Korea. Multivariable conditional logistic regression analysis was performed to determine the association of HCC with statin use.

The use of statins was significantly less common in 1,642 HCC patients than in 8,210 age-, sex- and index date-matched controls, including simvastatin (odds ratio [OR], 0.44; 95 percent CI, 0.33–0.58), atorvastatin (OR, 0.49; 0.37–0.65), lovastatin (OR, 0.34; 0.16–0.73), rosuvastatin (OR, 0.56; 0.31–0.98) and pitavastatin (OR, 0.31; 0.13–0.77).

There was a significant association between statin use and a lower risk of HCC incidence relative to nonuse (adjusted OR, 0.44; 0.33–0.58).

Cumulative doses of statin also appeared to yield a trend of risk reduction. The corresponding adjusted ORs for <180, 180–365, 365–720 and 720 cumulative defined daily doses of statin use were 0.45 (0.32–0.64), 0.56 (0.31–1.00), 0.41 (0.22–0.76) and 0.30 (0.14–0.63).

The inhibitory effect of statins on HCC was stronger in patients with DM (adjusted OR, 0.28; 0.17–0.46) and LC (adjusted OR, 0.39; 0.26–0.70) relative to statin users without the said conditions (adjusted OR for DM, 0.53; 0.39–0.73; adjusted OR for LC, 0.42; 0.32–0.57).

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Most Read Articles
18 Apr 2018
Higher intake levels of coffee appear to be associated with reduced risk of developing chronic kidney disease, according to data from the Atherosclerosis Risk in Communities Study.
Jairia Dela Cruz, 20 Apr 2018
Infants delivered via caesarean section may be at increased risk of developing acute lymphoblastic leukaemia, according to a US study. Altered microbiota colonization is a possible explanation for this risk, although clear biological mechanisms have yet to be established.
6 days ago
Treatment with danegaptide does not improve myocardial salvage in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention, according to the results of a phase II study.
Pearl Toh, 4 days ago
Tai Chi may be equivalent to pulmonary rehabilitation (PR) in improving health status of patients with chronic obstructive pulmonary disease (COPD), a recent study shows.