Most Read Articles
Roshini Claire Anthony, 29 May 2020

For coffee drinkers, drinking filtered coffee may be tied to a lower mortality risk, including cardiovascular disease (CVD)-related mortality, a study from Norway suggested.

3 days ago
Use of metformin is effective in preventing hyperglycaemia in nondiabetic cancer patients exposed to high-dose prednisone-based chemotherapy, results of a randomized study have shown.
6 days ago
Use of corticosteroid is not associated with improved outcomes in idiopathic pulmonary fibrosis (IPF) patients admitted to the hospital with acute exacerbation (AE), reveals a recent study. In addition, corticosteroids may even contribute to reduced overall survival following exacerbation.
Dr. Wong Soon Tee, 28 May 2020
Acne is a common skin problem seen in primary care. Dr Wong Soon Tee of Assurance Skin Clinic at Mt Elizabeth Novena Hospital, Singapore shares his insights with Pearl Toh on how to manage acne in the primary care setting.

Statins may prevent mortality in older adults with hypercholesterolaemia

18 Apr 2020

Statins appear to be useful as a primary prevention treatment in older adults with hypercholesterolaemia, reports a new meta-analysis.

From the databases of Medline, Embase and the Cochrane Library, researchers retrieved 35 randomized controlled trials eligible for analysis. The main study outcome was all-cause mortality and was assessed using the frequentist and the Bayesian approaches.

Cumulatively, 192,079 patients were included in the study, of whom 18,260 died. Fourteen of the included studies had participants that were only <75 years of age.

Analyses were categorized according to age. There were 14,483 participants who were older than 75 years, with an average age of 78.8±2.8 years. In this subgroup, 3,189 had died. In terms of nonfatal events, 5.8 percent had myocardial infarctions, 2.3 percent underwent percutaneous coronary interventions/coronary artery bypass grafting, and 3.5 percent developed strokes.

Bayesian analysis revealed a risk ratio for death that was less than zero, along with the upper bound of its 95 percent confidence interval. This suggested that elderly adults can derive survival benefits from prevention treatment with statins (p=0.03). No such effect was detected by the frequentist analysis.

“Current guidelines for the management for hypercholesterolaemia both in the US and Europe do not recommend statins for older people for primary prevention,” the researchers said. “The primary reason for this lack of recommendation to treat was that there were no sufficient clinical trial data to recommend treatment in this population subset.”

The frequentist analysis supports this treatment protocol, while the Bayesian approach does not. Further studies are required to address this.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Roshini Claire Anthony, 29 May 2020

For coffee drinkers, drinking filtered coffee may be tied to a lower mortality risk, including cardiovascular disease (CVD)-related mortality, a study from Norway suggested.

3 days ago
Use of metformin is effective in preventing hyperglycaemia in nondiabetic cancer patients exposed to high-dose prednisone-based chemotherapy, results of a randomized study have shown.
6 days ago
Use of corticosteroid is not associated with improved outcomes in idiopathic pulmonary fibrosis (IPF) patients admitted to the hospital with acute exacerbation (AE), reveals a recent study. In addition, corticosteroids may even contribute to reduced overall survival following exacerbation.
Dr. Wong Soon Tee, 28 May 2020
Acne is a common skin problem seen in primary care. Dr Wong Soon Tee of Assurance Skin Clinic at Mt Elizabeth Novena Hospital, Singapore shares his insights with Pearl Toh on how to manage acne in the primary care setting.