Most Read Articles
Pearl Toh, 01 Apr 2020
Short-term treatment (6 weeks) with 10 mg prednisolone effectively reduces finger pain and improves function in patients who have painful hand osteoarthritis (OA) coupled with signs of inflammation, the HOPE* study has shown.
31 Mar 2020
When treating fibromyalgia patients with low-dose naltrexone, the 4.5-mg dose appears to be a good choice, according to a recent study.
Elaine Soliven, 21 Apr 2020
Adding liraglutide to first-line lifestyle therapy led to a significantly reduced BMI standard-deviation score (BMI SDS*) among obese adolescents who failed to respond to lifestyle therapy alone, according to a study presented at ENDO 2020.
Elvira Manzano, 04 Mar 2020
Some patients with colitis are more likely than others to develop cuffitis after proctocolectomy with ileal pouch-anal anastomosis (IPAA), according to a retrospective study presented at the annual Crohn’s & Colitis Congress.

Statins may positively affect hepatocellular carcinoma risk in NAFLD patients

10 Oct 2019

Use of statins appears to reduce the risk of developing hepatocellular carcinoma (HCC) in patients with nonalcoholic fattly liver disease (NAFLD), whereas hypertension conferred a risk increase, according to a retrospective case-control study.

Researchers reviewed the medical records of 102 NAFLD patients (mean age, 69 years; 65 percent male) who underwent at least two computed tomography scans. Of these patients, 34 were HCC patients and 68 were matched non-HCC controls. NAFLD-HCC cases were confirmed on contrast imaging and/or biopsy.

The majority of the population had cirrhosis (91 percent). Multivariate logistic regression analysis showed statin use to be protective against HCC (odds ratio [OR], 0.20, 95 percent CI, 0.07–0.60; p=0.004), while hypertension was associated with a greater likelihood of HCC (OR, 5.80, 2.01–16.75; p=0.001).

On further analysis, visceral adipose tissue in males was higher before HCC development and decreased upon diagnosis in 86 percent, which was significantly different compared with controls (OR, 2.78, 1.10–7.44; p=0.04). Visceral adiposity at baseline was not a risk factor for HCC.

In a separate study, statins also exerted a beneficial inhibitory effect on HCC development, with the effect more pronounced in patients with liver cirrhosis or diabetes mellitus—conditions that are associated with a higher risk of HCC. [J Hepatol 2018;68:476-484]

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Most Read Articles
Pearl Toh, 01 Apr 2020
Short-term treatment (6 weeks) with 10 mg prednisolone effectively reduces finger pain and improves function in patients who have painful hand osteoarthritis (OA) coupled with signs of inflammation, the HOPE* study has shown.
31 Mar 2020
When treating fibromyalgia patients with low-dose naltrexone, the 4.5-mg dose appears to be a good choice, according to a recent study.
Elaine Soliven, 21 Apr 2020
Adding liraglutide to first-line lifestyle therapy led to a significantly reduced BMI standard-deviation score (BMI SDS*) among obese adolescents who failed to respond to lifestyle therapy alone, according to a study presented at ENDO 2020.
Elvira Manzano, 04 Mar 2020
Some patients with colitis are more likely than others to develop cuffitis after proctocolectomy with ileal pouch-anal anastomosis (IPAA), according to a retrospective study presented at the annual Crohn’s & Colitis Congress.