Most Read Articles
Audrey Abella, 15 May 2020
In adults with atrial fibrillation (AF) after percutaneous coronary intervention (PCI), dual therapy (direct oral anticoagulant [DOAC] + P2Y12 inhibitor) reduces the risk of bleeding compared with triple therapy (vitamin K antagonist [VKA] + DAPT* [aspirin and P2Y12 inhibitor]), a meta-analysis has shown. However, its effects on the risks of mortality and ischaemic endpoints** remain unclear.
09 May 2020
Use of aspirin during the implantation window of the menstrual cycle appears to increase fecundability, reveals a recent study.
Rachel Soon, 08 Apr 2020

Guidelines for local pharmacists on what actions to take during the COVID-19 pandemic have been issued by the Malaysian Pharmaceutical Society (MPS).

Pearl Toh, 11 Jun 2019
The novel antibody-drug conjugate enfortumab vedotin showed promising clinical activity in patients with advanced and metastatic urothelial cancer for whom there is a high unmet need, according to the EV-201 study presented at the ASCO 2019 Meeting.

Statins may positively affect hepatocellular carcinoma risk in NAFLD patients

10 Oct 2019

Use of statins appears to reduce the risk of developing hepatocellular carcinoma (HCC) in patients with nonalcoholic fattly liver disease (NAFLD), whereas hypertension conferred a risk increase, according to a retrospective case-control study.

Researchers reviewed the medical records of 102 NAFLD patients (mean age, 69 years; 65 percent male) who underwent at least two computed tomography scans. Of these patients, 34 were HCC patients and 68 were matched non-HCC controls. NAFLD-HCC cases were confirmed on contrast imaging and/or biopsy.

The majority of the population had cirrhosis (91 percent). Multivariate logistic regression analysis showed statin use to be protective against HCC (odds ratio [OR], 0.20, 95 percent CI, 0.07–0.60; p=0.004), while hypertension was associated with a greater likelihood of HCC (OR, 5.80, 2.01–16.75; p=0.001).

On further analysis, visceral adipose tissue in males was higher before HCC development and decreased upon diagnosis in 86 percent, which was significantly different compared with controls (OR, 2.78, 1.10–7.44; p=0.04). Visceral adiposity at baseline was not a risk factor for HCC.

In a separate study, statins also exerted a beneficial inhibitory effect on HCC development, with the effect more pronounced in patients with liver cirrhosis or diabetes mellitus—conditions that are associated with a higher risk of HCC. [J Hepatol 2018;68:476-484]

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Most Read Articles
Audrey Abella, 15 May 2020
In adults with atrial fibrillation (AF) after percutaneous coronary intervention (PCI), dual therapy (direct oral anticoagulant [DOAC] + P2Y12 inhibitor) reduces the risk of bleeding compared with triple therapy (vitamin K antagonist [VKA] + DAPT* [aspirin and P2Y12 inhibitor]), a meta-analysis has shown. However, its effects on the risks of mortality and ischaemic endpoints** remain unclear.
09 May 2020
Use of aspirin during the implantation window of the menstrual cycle appears to increase fecundability, reveals a recent study.
Rachel Soon, 08 Apr 2020

Guidelines for local pharmacists on what actions to take during the COVID-19 pandemic have been issued by the Malaysian Pharmaceutical Society (MPS).

Pearl Toh, 11 Jun 2019
The novel antibody-drug conjugate enfortumab vedotin showed promising clinical activity in patients with advanced and metastatic urothelial cancer for whom there is a high unmet need, according to the EV-201 study presented at the ASCO 2019 Meeting.