Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 3 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.
3 days ago
Use of thyroid hormone therapy does not seem to protect older adults with subclinical hypothyroidism against mortality, but it appears to confer survival benefits to those aged <65 years, results of a study have shown.

Statins confer protection against hepatocellular carcinoma in NAFLD patients

16 Aug 2020
Statins may have benefits in cancer treatment.

Statin use demonstrates a protective effect against hepatocellular carcinoma (HCC), while hypertension confers an increased risk, in patients with nonalcoholic fatty liver disease (NAFLD), a study has found.

Visceral adiposity at baseline, although not a risk factor, is higher in male patients before HCC development, declining in the majority by HCC diagnosis, according to the authors.

A retrospective case-control study was conducted on HCC cases from a cohort of NAFLD patients who underwent at least two computed tomography (CT) scans. NAFLD-HCC cases confirmed on contrast imaging or biopsy were included in the analysis. NAFLD patients without HCC matched by sex and age were selected as controls.

The authors assessed clinical variables and measured visceral adipose tissue and subcutaneous adipose tissue by CT scan at two timepoints: before HCC diagnosis and at diagnosis.

Of the 102 participants identified in this study from 2002 to 2016, 34 were HCC patients and 68 were controls (mean age, 69 years; 65 percent males). Ninety-one percent of them had cirrhosis.

Multivariable analysis revealed the protective benefit of statin use against HCC (odds ratio [OR], 0.20, 95 percent confidence interval [CI], 0.07–0.60; p=0.004) and the increased risk for HCC among those with hypertension (OR, 5.80, 95 percent CI, 2.01–16.75; p=0.001).

In addition, visceral adipose tissue in males was higher prior to HCC diagnosis and decreased at HCC diagnosis in 86 percent, which was significantly different as compared with controls (OR, 2.78, 95 percent CI, 1.10–7.44; p=0.04).

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 3 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.
3 days ago
Use of thyroid hormone therapy does not seem to protect older adults with subclinical hypothyroidism against mortality, but it appears to confer survival benefits to those aged <65 years, results of a study have shown.