Most Read Articles
Roshini Claire Anthony, 12 Nov 2018

Patients with mild hypertension who are at low risk for cardiovascular disease (CVD) do not appear to derive mortality or CVD benefit from antihypertensive treatments, raising questions on the need for treatment in this population, according to a recent study from England.

Pearl Toh, 09 Nov 2018
A personalized computerized neurofeedback intervention for training attention and memory shows potential in cognitive training for healthy elderly men, who improved in cognitive performance after the training, although no significant improvements were seen in the overall study population.
14 Nov 2018
Type 1 diabetes impairs cognitive functioning in children, and this effect is exacerbated by extreme glycaemic levels, according to a recent meta-analysis.
3 days ago
Higher exposure to ticagrelor following myocardial infarction does not appear to contribute to an increased risk of intracranial haemorrhage, which is associated with age and prior cardiovascular morbidities, according to a study.

Statins boosted by premeal psyllium fibre

20 Oct 2018
Statin side effects are found to be largely related to patients’ negative expectations.

Concomitant use of psyllium fibres, taken before meals, appears to enhance the cholesterol-lowering effects of statins, according to a recent meta-analysis.

The systematic review yielded three randomized controlled clinical studies eligible for inclusion. Two studies enrolled participants with high low-density lipoprotein cholesterol (LDL-C) levels at baseline, one of which assessed the efficacy of atorvastatin (study 1) while the other, simvastatin (study 2). The third study involved healthy individuals with normal baseline LDL-C.

In both studies with hypercholesterolaemic participants, psyllium supplementation improved the effects of statins. For instance, in study 2, a lower dose of simvastatin (10 mg), when given with 15.3 g/day of psyllium fibre, delivered a similar efficacy to that of the 20-mg dose. The same was true for study 3, which employed lovastatin.

The meta-analysis showed that study 1 (standard difference in means, –0.541; 95 percent CI, –0.959 to –0.134; p=0.009) and study 2 (standard difference in means, –0.661; –1.225 to –0.068; p=0.029) demonstrated the largest effects, with both studies showing a statistically significant advantage of psyllium supplementation to statin treatment alone.

This effect was absent in study 3 (standard differences in means, –0.229; –1.032 to 0.573; p=0.576), which was expected.

Pooling all three studies together showed that psyllium fibre supplementation significantly improved the efficacy of statins in reducing LDL-C levels (standard differences in means, –0.528; –0.837 to –0.218; p=0.001).

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Most Read Articles
Roshini Claire Anthony, 12 Nov 2018

Patients with mild hypertension who are at low risk for cardiovascular disease (CVD) do not appear to derive mortality or CVD benefit from antihypertensive treatments, raising questions on the need for treatment in this population, according to a recent study from England.

Pearl Toh, 09 Nov 2018
A personalized computerized neurofeedback intervention for training attention and memory shows potential in cognitive training for healthy elderly men, who improved in cognitive performance after the training, although no significant improvements were seen in the overall study population.
14 Nov 2018
Type 1 diabetes impairs cognitive functioning in children, and this effect is exacerbated by extreme glycaemic levels, according to a recent meta-analysis.
3 days ago
Higher exposure to ticagrelor following myocardial infarction does not appear to contribute to an increased risk of intracranial haemorrhage, which is associated with age and prior cardiovascular morbidities, according to a study.