Most Read Articles
2 days ago
Older women with longer endogenous oestrogen exposure and hormone therapy use are at much higher odds of having favourable cognitive status in late life, a recent study suggests.
Tristan Manalac, 5 days ago
The likelihood of distal stent graft-induced new entry (dSINE) is compounded by an excessive distal oversizing ratio and chronic type B aortic dissection (TBAD), according to a new Singapore meta-analysis.
Elvira Manzano, Yesterday
Supplementation with omega-3 fatty acids or vitamin D3 for up to 5 years has no effect on kidney function in adults with type 2 diabetes (T2D), the VITAL-DKD* ancillary study has shown.
2 days ago
Better sleep appears to weaken pain and fatigue in older, community-dwelling adults with hip or knee osteoarthritis (OA), reports a recent study.

Statins boost survival among seniors with rectal cancer

17 Sep 2019
Statin, a blood cholesterol-lowering medicine, reduces sharply in blood cholesterol levels among ACS patients.

Using statins may improve survival among elderly adults with rectal cancer, a recent study has shown.

Researchers enrolled 465 elderly adults, who were categorized into two age groups: 70 years (n=238) and <70 years (n=227). Those who were using statins at the time of cancer diagnosis were designated as users, while those who weren’t were identified as nonusers. The primary study outcomes were cancer-specific (CSS), overall (OS) and disease-free (DFS) survival rates.

There were more nonusers than users at the time of rectal cancer diagnosis in both the younger (197 vs 30) and older (180 vs 58) age groups. The difference in the rate of use between groups was statistically significant (13 percent vs 24 percent, respectively; p=0.002).

In the older age group, statin use significantly increased CSS (adjusted hazard ratio [HR], 0.42, 95 percent CI, 0.21–0.84; p=0.013) and OS (adjusted HR, 0.59, 0.36–0.95; p=0.029) relative to nonuse. No such effect was reported for the younger age group (CSS: HR, 0.71, 0.31–1.66; p=0.429; OS: HR, 0.76, 0.38–1.53; p=0.445).

Similarly, statin use led to a significantly better DFS in participants in the older group with stage I–III disease (adjusted HR, 0.20, 0.06–0.65; p=0.008). No such effect was reported for the younger group (HR, 1.19, 0.53–2.69; p=0.668).

Statin use also significantly reduced the likelihood of distant recurrence in the older group (16 percent vs 36 percent; p=0.004) but not in the younger group (p=0.489). Statins had no influence on the risk of local recurrence.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
2 days ago
Older women with longer endogenous oestrogen exposure and hormone therapy use are at much higher odds of having favourable cognitive status in late life, a recent study suggests.
Tristan Manalac, 5 days ago
The likelihood of distal stent graft-induced new entry (dSINE) is compounded by an excessive distal oversizing ratio and chronic type B aortic dissection (TBAD), according to a new Singapore meta-analysis.
Elvira Manzano, Yesterday
Supplementation with omega-3 fatty acids or vitamin D3 for up to 5 years has no effect on kidney function in adults with type 2 diabetes (T2D), the VITAL-DKD* ancillary study has shown.
2 days ago
Better sleep appears to weaken pain and fatigue in older, community-dwelling adults with hip or knee osteoarthritis (OA), reports a recent study.