Most Read Articles
4 days ago
Children with high dental anxiety are more likely to develop dental diseases, which, in turn, negatively affect the family’s quality of life, a recent study has found.
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Statins boost survival among seniors with rectal cancer

17 Sep 2019
Statin, a blood cholesterol-lowering medicine, reduces sharply in blood cholesterol levels among ACS patients.

Using statins may improve survival among elderly adults with rectal cancer, a recent study has shown.

Researchers enrolled 465 elderly adults, who were categorized into two age groups: 70 years (n=238) and <70 years (n=227). Those who were using statins at the time of cancer diagnosis were designated as users, while those who weren’t were identified as nonusers. The primary study outcomes were cancer-specific (CSS), overall (OS) and disease-free (DFS) survival rates.

There were more nonusers than users at the time of rectal cancer diagnosis in both the younger (197 vs 30) and older (180 vs 58) age groups. The difference in the rate of use between groups was statistically significant (13 percent vs 24 percent, respectively; p=0.002).

In the older age group, statin use significantly increased CSS (adjusted hazard ratio [HR], 0.42, 95 percent CI, 0.21–0.84; p=0.013) and OS (adjusted HR, 0.59, 0.36–0.95; p=0.029) relative to nonuse. No such effect was reported for the younger age group (CSS: HR, 0.71, 0.31–1.66; p=0.429; OS: HR, 0.76, 0.38–1.53; p=0.445).

Similarly, statin use led to a significantly better DFS in participants in the older group with stage I–III disease (adjusted HR, 0.20, 0.06–0.65; p=0.008). No such effect was reported for the younger group (HR, 1.19, 0.53–2.69; p=0.668).

Statin use also significantly reduced the likelihood of distant recurrence in the older group (16 percent vs 36 percent; p=0.004) but not in the younger group (p=0.489). Statins had no influence on the risk of local recurrence.

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Most Read Articles
4 days ago
Children with high dental anxiety are more likely to develop dental diseases, which, in turn, negatively affect the family’s quality of life, a recent study has found.
2 days ago
Exposure to corticosteroids in patients with autoimmune hepatitis (AIH) appears to contribute to increased risks of cataract, diabetes and bone fractures, a study has found. Notably, the fracture risk is elevated at low doses, while the risk of adverse events overall is dose-dependent and is reversible.
14 Nov 2019
In patients with atrial fibrillation (AF) and stable coronary artery disease (CAD), rivaroxaban monotherapy is noninferior to combination treatment with an antiplatelet therapy in terms of cutting the risk of cardiovascular events and mortality, according to data from the AFIRE trial.
3 days ago
Supplementation with oral nano vitamin D appears to moderate disease activity and severity grade of patients with active ulcerative colitis (UC), suggests a study, adding that this association is more evident in those achieving a target vitamin D level of 40 ng/mL.