Most Read Articles
6 days ago
Older women with longer endogenous oestrogen exposure and hormone therapy use are at much higher odds of having favourable cognitive status in late life, a recent study suggests.
3 days ago
In patients with atrial fibrillation (AF) and stable coronary artery disease (CAD), rivaroxaban monotherapy is noninferior to combination treatment with an antiplatelet therapy in terms of cutting the risk of cardiovascular events and mortality, according to data from the AFIRE trial.
Elvira Manzano, 4 days ago
Supplementation with omega-3 fatty acids or vitamin D3 for up to 5 years has no effect on kidney function in adults with type 2 diabetes (T2D), the VITAL-DKD* ancillary study has shown.
Jairia Dela Cruz, 2 days ago
Many patients with nonvalvular atrial fibrillation (NVAF) in Thailand use anticoagulants, but the uptake of nonvitamin-K oral anticoagulants remains suboptimal despite showing an upward trend, according to data from the COOL-AF registry presented at the European Society of Cardioloy (ESC) Asia Congress 2019 with APSC and AFC.

Statins boost survival among seniors with rectal cancer

17 Sep 2019
Statin, a blood cholesterol-lowering medicine, reduces sharply in blood cholesterol levels among ACS patients.

Using statins may improve survival among elderly adults with rectal cancer, a recent study has shown.

Researchers enrolled 465 elderly adults, who were categorized into two age groups: 70 years (n=238) and <70 years (n=227). Those who were using statins at the time of cancer diagnosis were designated as users, while those who weren’t were identified as nonusers. The primary study outcomes were cancer-specific (CSS), overall (OS) and disease-free (DFS) survival rates.

There were more nonusers than users at the time of rectal cancer diagnosis in both the younger (197 vs 30) and older (180 vs 58) age groups. The difference in the rate of use between groups was statistically significant (13 percent vs 24 percent, respectively; p=0.002).

In the older age group, statin use significantly increased CSS (adjusted hazard ratio [HR], 0.42, 95 percent CI, 0.21–0.84; p=0.013) and OS (adjusted HR, 0.59, 0.36–0.95; p=0.029) relative to nonuse. No such effect was reported for the younger age group (CSS: HR, 0.71, 0.31–1.66; p=0.429; OS: HR, 0.76, 0.38–1.53; p=0.445).

Similarly, statin use led to a significantly better DFS in participants in the older group with stage I–III disease (adjusted HR, 0.20, 0.06–0.65; p=0.008). No such effect was reported for the younger group (HR, 1.19, 0.53–2.69; p=0.668).

Statin use also significantly reduced the likelihood of distant recurrence in the older group (16 percent vs 36 percent; p=0.004) but not in the younger group (p=0.489). Statins had no influence on the risk of local recurrence.

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Most Read Articles
6 days ago
Older women with longer endogenous oestrogen exposure and hormone therapy use are at much higher odds of having favourable cognitive status in late life, a recent study suggests.
3 days ago
In patients with atrial fibrillation (AF) and stable coronary artery disease (CAD), rivaroxaban monotherapy is noninferior to combination treatment with an antiplatelet therapy in terms of cutting the risk of cardiovascular events and mortality, according to data from the AFIRE trial.
Elvira Manzano, 4 days ago
Supplementation with omega-3 fatty acids or vitamin D3 for up to 5 years has no effect on kidney function in adults with type 2 diabetes (T2D), the VITAL-DKD* ancillary study has shown.
Jairia Dela Cruz, 2 days ago
Many patients with nonvalvular atrial fibrillation (NVAF) in Thailand use anticoagulants, but the uptake of nonvitamin-K oral anticoagulants remains suboptimal despite showing an upward trend, according to data from the COOL-AF registry presented at the European Society of Cardioloy (ESC) Asia Congress 2019 with APSC and AFC.