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Statin use may lower risks of osteoporosis, fracture in stroke patients

11 Oct 2018

Use of statin appears to reduce the risks of osteoporosis, hip fractures and vertebral fracture in patients newly diagnosed with a stroke, suggests a recent study.

Poststroke statin use correlated with a decreased overall risk of the primary outcome of osteoporosis, hip fractures and vertebral fracture (adjusted hazard ratio [aHR], 0.66; p<0.001). Subanalyses revealed a correlation between statin use and a lower risk of all individual outcomes, including osteoporosis (aHR, 0.68; p<0.001), hip fracture (aHR, 0.59; p<0.001) and vertebral fracture (aHR, 0.73; p=0.003).

There was a dose-effect relationship between the outcomes and statin use. The aHRs for developing the primary outcome were 0.96 for patients who used 1–90 cumulative defined daily doses of statins, 0.86 for 91–365 and 0.34 for >365. These dose-effect relationships persisted in subgroup analyses stratified by age, sex and stroke type and sensitivity analyses conducted without propensity score matching.

This population-based propensity score-matched cohort study examined the association between statin use and risks of osteoporosis and fracture in stroke patients using Taiwan’s National Health Insurance Research Database.

The authors identified patients newly diagnosed with a stroke between 2000 and 2012. A total of 5,254 patients were included after propensity-score matching. Cox proportional hazards regression models according to statin use status were generated to calculate HRs for poststroke osteoporosis, hip fracture and vertebral fracture.

“Poststroke osteoporosis and consequent fractures increase the risk of morbidity and mortality and cause considerable socioeconomic burden,” the authors noted.

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Most Read Articles
Pearl Toh, 6 days ago
First-line therapy with the BTK* inhibitor ibrutinib plus the anti-CD20 immunotherapy rituximab confers significant survival advantage over the current gold-standard regimen of fludarabine, cyclophosphamide, and rituximab (FCR) for young, fit patients with treatment-naïve chronic lymphocytic leukaemia (CLL), according to the E1912 trial, a large cooperative group study supported by the US National Cancer Institute.
Dr Renly Lim, 01 Aug 2018
Palliative care uses an integrated, multidisciplinary approach to reduce suffering and to improve the quality of life of patients battling with life-threatening illnesses.
29 Jan 2017
The over-the-counter cough medicine CS1002 does not appear to induce a significant improvement in cough severity, although it may produce greater reductions in cough frequency and sleep disruption compared with simple linctus (SL), according to a study. Furthermore, the drug is associated with increased resolution of cough, resulting in early treatment discontinuation and improved health status.
Rachel Soon, 12 Dec 2018

MIMS Pharmacist speaks to Cpt. Manvikram Singh Gill, military pharmacist with the Royal Medical and Dental Corps (RMDC) of the Malaysian Armed Forces (MAF),about his work at the Rohingya refugee camp in Cox's Bazar, Bangladesh.