Most Read Articles
Jairia Dela Cruz, 14 Jan 2019
The potassium-competitive acid blocker vonoprazan demonstrates superior efficacy in the treatment of patients with erosive oesophagitis compared with the proton pump inhibitor lansoprazole, with the results of a small trial showing that the former more rapidly provides complete sustained heartburn relief during the first week of therapy.
01 Mar 2016
Bathing with 2% chlorhexidine gluconate-medicated washcloth is cost-effective for the prevention of central line-associated bloodstream infection (CLABSI), based on a systematic review and meta-analysis of four studies.
08 Jan 2019
Treatment with spironolactone has shown consistent, albeit modest, clinical effectiveness in older patients with heart failure with reduced ejection fraction (HFrEF) regardless of renal eligibility criteria used, a recent study has shown.
Rachel Soon, 12 Dec 2018

MIMS Pharmacist presents an overview of superoxide dismutase (SOD) and its role in resisting the effects of oxidative stress and aging.

Statin use may lower risks of osteoporosis, fracture in stroke patients

11 Oct 2018

Use of statin appears to reduce the risks of osteoporosis, hip fractures and vertebral fracture in patients newly diagnosed with a stroke, suggests a recent study.

Poststroke statin use correlated with a decreased overall risk of the primary outcome of osteoporosis, hip fractures and vertebral fracture (adjusted hazard ratio [aHR], 0.66; p<0.001). Subanalyses revealed a correlation between statin use and a lower risk of all individual outcomes, including osteoporosis (aHR, 0.68; p<0.001), hip fracture (aHR, 0.59; p<0.001) and vertebral fracture (aHR, 0.73; p=0.003).

There was a dose-effect relationship between the outcomes and statin use. The aHRs for developing the primary outcome were 0.96 for patients who used 1–90 cumulative defined daily doses of statins, 0.86 for 91–365 and 0.34 for >365. These dose-effect relationships persisted in subgroup analyses stratified by age, sex and stroke type and sensitivity analyses conducted without propensity score matching.

This population-based propensity score-matched cohort study examined the association between statin use and risks of osteoporosis and fracture in stroke patients using Taiwan’s National Health Insurance Research Database.

The authors identified patients newly diagnosed with a stroke between 2000 and 2012. A total of 5,254 patients were included after propensity-score matching. Cox proportional hazards regression models according to statin use status were generated to calculate HRs for poststroke osteoporosis, hip fracture and vertebral fracture.

“Poststroke osteoporosis and consequent fractures increase the risk of morbidity and mortality and cause considerable socioeconomic burden,” the authors noted.

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Most Read Articles
Jairia Dela Cruz, 14 Jan 2019
The potassium-competitive acid blocker vonoprazan demonstrates superior efficacy in the treatment of patients with erosive oesophagitis compared with the proton pump inhibitor lansoprazole, with the results of a small trial showing that the former more rapidly provides complete sustained heartburn relief during the first week of therapy.
01 Mar 2016
Bathing with 2% chlorhexidine gluconate-medicated washcloth is cost-effective for the prevention of central line-associated bloodstream infection (CLABSI), based on a systematic review and meta-analysis of four studies.
08 Jan 2019
Treatment with spironolactone has shown consistent, albeit modest, clinical effectiveness in older patients with heart failure with reduced ejection fraction (HFrEF) regardless of renal eligibility criteria used, a recent study has shown.
Rachel Soon, 12 Dec 2018

MIMS Pharmacist presents an overview of superoxide dismutase (SOD) and its role in resisting the effects of oxidative stress and aging.