Most Read Articles
6 days ago
A strong belief in the necessity of medication is associated with better adherence to oral disease-modifying antirheumatic drugs (DMARDs) or prednisone, while higher self-efficacy correlates with poor adherence, in a diverse cohort of patients with rheumatoid arthritis (RA), suggests a study.
5 days ago
Low-dose administrations of haloperidol after thoracic surgery does not appear to prevent postoperative delirium, according to a new study.
3 days ago
Percutaneous coronary intervention (PCI) displays comparable rates of mortality and serious composite outcomes but a higher rate of target-vessel revascularization at 10 years relative to coronary artery bypass grafting (CABG) in patients with significant left main coronary artery (LMCA) disease, reports a study. On the other hand, CABG delivers lower mortality and serious composite outcome rates compared with PCI with drug-eluting stents after 5 years.
Pearl Toh, 4 days ago
Apixaban slashes the risk of recurrent venous thromboembolism (VTE) by 90 percent in cancer patients compared with the low-molecular-weight heparin (LMWH) dalteparin, with no increase in major bleeding risk, according to the ADAM VTE study presented at ASH 2018.

Statin use after oesophageal cancer diagnosis may improve survival

12 Oct 2018
Statin, a blood cholesterol-lowering medicine, reduces sharply in blood cholesterol levels among ACS patients.

The use of statins after diagnosis seems to improve survival in patients with oesophageal cancer, a recent study has found.

Researchers enrolled 7,882 oesophageal adenocarcinoma (EAC) and 3,868 oesophageal squamous cell carcinoma (ESCC) patients, in whom the pre- and postdiagnosis treatments with statins were determined from pharmacy records. A 3-month lag in the analysis was employed to reduce the likelihood of reverse causation.

In the EAC group, 2,160 participants (mean age 67.4±8.2 years; 99.5 percent male) had reported statin use while the remaining 5,722 (mean age 66.5±9.8 years; 99.3 percent male) did not. In comparison, there were 661 users (mean age 68.5±8.5 years; 98.9 percent male) and 3,207 nonusers (mean age 66.1±9.8 years; 98.7 percent male) in the ESCC group.

Majority of the patients died during follow-up (EAC: 84 percent; ESCC: 91.5 percent). The median survival times were 13.5 months and 11.0 months in the EAC and ESCC cohorts, respectively.

Postdiagnosis statin use was reported in 27.4 percent of EAC patients, in whom the median survival time was significantly greater than that in nonusers (23.0 vs 11.0 months; p<0.001). Cancer-specific (adjusted hazard ratio [HR], 0.79; 95 percent CI, 0.70–0.88) and all-cause (adjusted HR, 0.80; 0.74–0.86) mortality risks were significantly lower in statin users.

The same was true for ESCC patients. The median survival time for statin users was 22.4 months, which was significantly longer than the 9.79 months in nonusers. The risks of cancer-specific (adjusted HR, 0.77; 0.63–0.92) and all-cause (adjusted HR, 0.83; 0.74–0.95) mortality were likewise significantly reduced in statin users vs nonusers.

However, in a subsequent analysis that introduced a 6-month lag, “the effect estimates for statin use on mortality were attenuated towards the null and indicated, at most, a 10-percent lower risk of mortality associated with postdiagnosis statin use,” said researchers.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Gastroenterology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
6 days ago
A strong belief in the necessity of medication is associated with better adherence to oral disease-modifying antirheumatic drugs (DMARDs) or prednisone, while higher self-efficacy correlates with poor adherence, in a diverse cohort of patients with rheumatoid arthritis (RA), suggests a study.
5 days ago
Low-dose administrations of haloperidol after thoracic surgery does not appear to prevent postoperative delirium, according to a new study.
3 days ago
Percutaneous coronary intervention (PCI) displays comparable rates of mortality and serious composite outcomes but a higher rate of target-vessel revascularization at 10 years relative to coronary artery bypass grafting (CABG) in patients with significant left main coronary artery (LMCA) disease, reports a study. On the other hand, CABG delivers lower mortality and serious composite outcome rates compared with PCI with drug-eluting stents after 5 years.
Pearl Toh, 4 days ago
Apixaban slashes the risk of recurrent venous thromboembolism (VTE) by 90 percent in cancer patients compared with the low-molecular-weight heparin (LMWH) dalteparin, with no increase in major bleeding risk, according to the ADAM VTE study presented at ASH 2018.