Most Read Articles
27 Mar 2018
Combination treatment with hydrocortisone plus fludrocortisone reduces 90-day all-cause mortality in patients with septic shock, a study has found.
Rachel Soon, 16 Mar 2018

Intake of calcium supplements may up the risk of developing sessile serrated adenomas or polyps (SSA/Ps) in the colon, according to a new study.

30 Nov 2017
Fluarex Tetra - Inactivated quadrivalent influenza vaccine (split virion) vaccine (inj) 0.5 mL - GlaxoSmithKline
18 Apr 2018
In patients with rheumatoid arthritis (RA), temporary cessation of methotrexate (MTX) treatment for 2 weeks following influenza vaccination appears to improve the immunogenicity of the vaccine without increasing RA disease activity, according to a study.

Statin treatment linked to reduced severity of acute pancreatitis

04 Jan 2018

Statins appear to reduce the severity of acute pancreatitis (AP), as demonstrated by a decrease in overall incidence of multisystem organ failure (MSOF), according to a study.

Researchers examined the medical records of adult patients with AP admitted in the Cleveland Clinic Health System between 2007 and 2014. They performed a propensity-matched analysis to assess the effect of statin exposure on the severity of pancreatitis and incidence of organ failure. The propensity model included factors that influence statin use to minimize selection bias.

A total of 110 AP patients on statin at admission were matched with 210 AP patients who were not exposed to the drug. The two patient groups were evenly matched in terms of known baseline factors that may influence statin use and severity of pancreatitis.

Outcomes of interest were pancreatitis severity (Revised Atlanta Classification), incidence of MSOF, new MSOF, acute necrosis, and death. Additional surrogate markers of severity, such as hospital length of stay, Bedside Index of Severity of Acute Pancreatitis (BISAP), and presence of systemic inflammatory response syndrome, were also assessed.

Results revealed that statin use was associated with a lower likelihood of developing MOSF, severe AP, and necrosis. While there were fewer cases of in-hospital death in the statin group than in the unexposed group, the difference was not statistically significant (2 vs 4 percent; p=0.38).

In a previous animal study, statin administration resulted in lower severity of AP, reduced serum levels of interleukin-10, and diminished myeloperoxidase activity. Statins also demonstrated antioxidant effects and helped prevent cell damage. Specifically, pravastatin significantly attenuated the progression of pancreatic inflammation, fibrosis, and exocrine dysfunction, possibly through the drug’s antioxidative properties and overproduction of interleukin-10. On the other hand, lovastatin was associated with the inhibition of pancreatic stellate cell activation through the interruption of RAS signalling. [Am J Gastroenterol 2017;112:1765–1767]

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Most Read Articles
27 Mar 2018
Combination treatment with hydrocortisone plus fludrocortisone reduces 90-day all-cause mortality in patients with septic shock, a study has found.
Rachel Soon, 16 Mar 2018

Intake of calcium supplements may up the risk of developing sessile serrated adenomas or polyps (SSA/Ps) in the colon, according to a new study.

30 Nov 2017
Fluarex Tetra - Inactivated quadrivalent influenza vaccine (split virion) vaccine (inj) 0.5 mL - GlaxoSmithKline
18 Apr 2018
In patients with rheumatoid arthritis (RA), temporary cessation of methotrexate (MTX) treatment for 2 weeks following influenza vaccination appears to improve the immunogenicity of the vaccine without increasing RA disease activity, according to a study.