Most Read Articles
KY Leung, 01 Feb 2014

Group B Streptococcus (GBS) is the commonest cause of severe early-onset neonatal infection, which is associated with a high rate of morbidity and mortality (5–10%).1-3 About half of GBS meningitis will be complicated by neurodevelopment impairment. Because the early-onset disease develops shortly and rapidly after birth, there has been little improvement in the disease treatment, and the focus thus lies in disease prevention.

20 Jul 2017
Nutrition and Behaviour Modification for Picky Eaters (NBMPE) is a management plan for children with mild picky eating habits. An NBMPE Expert Programme was recently conducted by three of the expert panelists in Kuala Lumpur, which saw the participation of more than 30 paediatricians from across the country. The highlights from the event are summarized here.
Jairia Dela Cruz, 23 Oct 2017
Evacuation proctography, magnetic resonance imaging, and transperineal and endovaginal ultrasonography demonstrate similar diagnostic test accuracy for posterior pelvic floor disorders in women with obstructed defecation syndrome, a recent study has shown.
Dr. Joseph Delano Fule Robles, 14 Oct 2016

Results of a recent clinical trial showed that treatment with niraparib, a poly ADP ribose polymerase (PARP) inhibitor,  improved progression-free survival (PFS) by more than 15 months in patients with recurrent ovarian cancer responding to platinum. 

Standardized vs individualized oligomenorrhoea, amenorrhoea treatment using Chinese herbs

14 Feb 2017

Both standardized and individualized regimens of multiherb Chinese herbal medicine have comparable clinical efficacies and safeties when used to treat polycystic ovary syndrome-related amenorrhoea and oligomenorrhoea, a new study has shown.

The preliminary study involved 40 women between the ages of 18 and 40 years diagnosed with amenorrhea and oligomenorrhea. Those who were suspected to be pregnant, had other causes of menstrual irregularity actively trying to get pregnant, had a history of liver or kidney diseases or had a history of mental disorders were excluded.

The primary outcome was whether oligomenorrhea and amenorrhea were feasible as the main outcomes for randomized controlled trials. Effects of the treatment were evaluated according to safety, efficacy and acceptability.

Only 29 of the 40 participants were able to successfully complete the study. Hirsutism was the most common complaint reported, along with menstrual irregularity and weight.

Interestingly, after 6 months of the Chinese herbal medicine treatment, both standardized (mean difference [MD], 0.18±0.06; 95 percent CI, 0.06 to 0.29; p=0.0027) and individualized (MD, 0.27±0.06; 0.15 to 0.39; p<0.001) regimen groups reported significant in-group improvements in menstrual rate.

However, there was no reported significant difference in improvements between standardized and individualized treatments (p=0.26). Similarly, within-group improvements for hisrutism did not reach statistical significance when tested between groups.

There were no documented improvements in weight and BMI in either group. In terms of safety, kidney and liver function remained normal for both standardized and individualized regimens. Using a tablet for administration, as participant feedback suggested, might improve adherence.

The findings show that oligomenorrhea and amenorrhea are feasible outcomes for testing Chinese herbal medicine. Furthermore, primary findings imply efficacy, but without any difference between standardized and individualized treatment regimens.

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Most Read Articles
KY Leung, 01 Feb 2014

Group B Streptococcus (GBS) is the commonest cause of severe early-onset neonatal infection, which is associated with a high rate of morbidity and mortality (5–10%).1-3 About half of GBS meningitis will be complicated by neurodevelopment impairment. Because the early-onset disease develops shortly and rapidly after birth, there has been little improvement in the disease treatment, and the focus thus lies in disease prevention.

20 Jul 2017
Nutrition and Behaviour Modification for Picky Eaters (NBMPE) is a management plan for children with mild picky eating habits. An NBMPE Expert Programme was recently conducted by three of the expert panelists in Kuala Lumpur, which saw the participation of more than 30 paediatricians from across the country. The highlights from the event are summarized here.
Jairia Dela Cruz, 23 Oct 2017
Evacuation proctography, magnetic resonance imaging, and transperineal and endovaginal ultrasonography demonstrate similar diagnostic test accuracy for posterior pelvic floor disorders in women with obstructed defecation syndrome, a recent study has shown.
Dr. Joseph Delano Fule Robles, 14 Oct 2016

Results of a recent clinical trial showed that treatment with niraparib, a poly ADP ribose polymerase (PARP) inhibitor,  improved progression-free survival (PFS) by more than 15 months in patients with recurrent ovarian cancer responding to platinum.