Most Read Articles
04 Oct 2020
Obesity does not appear to be strongly correlated with an increased risk for febrile neutropaenia during levofloxacin prophylaxis in patients with haematological malignancies receiving intermediate-risk myelosuppressive chemotherapy, suggests a study.
Roshini Claire Anthony, 6 days ago

Initiation or switch to the single-tablet regimen of bictegravir/emtricitabine/tenofovir alafenamide (TAF) led to low HIV-1 RNA viral load in people living with HIV (PLHIV), according to the BICSTaR study presented at HIV Glasgow 2020.

09 Nov 2020
Use of corticosteroids appears to be an effective treatment for paediatric drug reaction with eosinophilia and systemic symptoms (DRESS), suggest the results of a recent study. In severe cases, corticosteroids used in conjunction with intravenous immunoglobulin result in fast clinical improvement.
Stephen Padilla, 10 Nov 2020
Patients with chronic obstructive pulmonary disease (COPD) seem to benefit from using chlorhexidine oral rinses twice daily as shown by the reduction in oral and sputum microbiota alpha diversity and by clinically significant improvements in COPD symptoms, according to a study presented at ID Week 2020.

Standardized order set during LVP safely lowers amount of albumin dosing

29 Sep 2020

Using an order set to guide albumin dosing based on the amount of ascitic fluid removed during large volume paracentesis (LVP) substantially reduces the quantity of albumin given with no difference in adverse effects, results of a study have shown.

The investigators examined the impact of implementing a standardized LVP order set on albumin utilization and patient outcomes in this retrospective review of patients with ascites due to cirrhosis who received a therapeutic paracentesis at a large, academic institution. Albumin doses were standardized in the order set to 25 g (5-6 L removed), 50 g (7-10 L), and 75 g (>10 L).

The amount of albumin used prior to and after order set implementation was the primary outcome. Other patient outcomes included rates of hyponatraemia, renal impairment, and hypotension.

Each arm included 100 patients in the final analysis. Patients prior to order set implementation received a higher amount of albumin per litre removed than those postimplementation (8.3 vs 6.5 g/L; p<0.01).

No significant between-group differences were seen in absolute changes in serum sodium (0 vs −1 mEq/L; p=0.64), serum creatinine (0.06 vs 0.05 mg/dL; p=0.94), or systolic blood pressure (−4 vs −3 mm Hg; p=0.96). No differences were also noted in rates of hyponatraemia (1.6 percent vs 6.6 percent; p=0.21), renal impairment (11.3 percent vs 11.5 percent; p=0.97), or hypotension (17.4 percent vs 17.6 percent; p=0.97) between the two groups.

“Albumin after LVP reduces paracentesis-induced circulatory dysfunction. The most efficacious dose of albumin for LVP is unclear,” the investigators said.

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Most Read Articles
04 Oct 2020
Obesity does not appear to be strongly correlated with an increased risk for febrile neutropaenia during levofloxacin prophylaxis in patients with haematological malignancies receiving intermediate-risk myelosuppressive chemotherapy, suggests a study.
Roshini Claire Anthony, 6 days ago

Initiation or switch to the single-tablet regimen of bictegravir/emtricitabine/tenofovir alafenamide (TAF) led to low HIV-1 RNA viral load in people living with HIV (PLHIV), according to the BICSTaR study presented at HIV Glasgow 2020.

09 Nov 2020
Use of corticosteroids appears to be an effective treatment for paediatric drug reaction with eosinophilia and systemic symptoms (DRESS), suggest the results of a recent study. In severe cases, corticosteroids used in conjunction with intravenous immunoglobulin result in fast clinical improvement.
Stephen Padilla, 10 Nov 2020
Patients with chronic obstructive pulmonary disease (COPD) seem to benefit from using chlorhexidine oral rinses twice daily as shown by the reduction in oral and sputum microbiota alpha diversity and by clinically significant improvements in COPD symptoms, according to a study presented at ID Week 2020.