Most Read Articles
5 days ago
In type 2 diabetes patients taking sulfonylureas, hypoglycaemia duration is longer at night and is inversely correlated with the level of glycated haemoglobin (HbA1c), a new study reports.
4 days ago
Podcast: Dr Shamir Mehta briefly discusses the clinical impact of findings from the COMPLETE trial
3 days ago
Podcast: Prof Derek Chew explains the importance of a 1-hour troponin T protocol in suspected ACS as discussed in the RAPID-TnT trial
4 days ago
Sodium-glucose transport protein 2 (SGLT2) inhibitors exert a putative epigenetic regulation of the protecting cardiovascular effect, reports a study, adding that dapagliflozin may protect the kidneys by preserving renal vasodilating capacity.

Specific supplementation limits adverse effects of combined oral contraceptives

26 Jul 2019

Supplementation with specific micronutrients results in a significant reduction in the frequency and severity of adverse effects during oral contraception treatment, a study has shown.

In particular, Centella Asiatica (CA) extract helps in moderating water retention, offsetting the consequent bodyweight increase as well as leg swelling and breast tenderness. Moreover, the combination of vitamins and minerals lessens the occurrence of migraine, helps increase energy levels and contributes to a better mood.

This controlled, pilot, prospective study included 52 healthy female volunteers who were prescribed an estroprogestinic contraceptive and were randomized to either the study group (n=26) or the control group (n=26). The former received a dietary supplement containing CA extract, vitamins and minerals, while the latter received only the estroprogestinic pill.

The authors measured baseline values at enrolment and assessed the outcomes after 3 months of intervention. They also measured bodyweight, body mass index (BMI) and extracellular body water using a bioelectrical impedance analysis (BIA) scale. Patients used a dedicated questionnaire to self-report their evaluation of cellulite, breast tenderness, leg swelling, mood, fatigue, migraine, vaginal discharge and hair dryness.

Three months of supplementation led to a visible decrease in cellulite level by 56 percent and in water retention by 4 percent relative to the control group. There were also significant improvements for the other outcomes.

Supplementation negated the adverse effect of estroprogestinic contraceptive by limiting water retention, bodyweight and BMI increase. It also improved the remaining outcomes in comparison to both the control group and baseline values.

“Discontinuation and poor compliance are leading causes of oral contraception failure,” the authors said. “Because of possible adverse effects that impact their quality of life, women skip their daily dose of contraceptive, or opt for different contraception methods.”

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Endocrinology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
5 days ago
In type 2 diabetes patients taking sulfonylureas, hypoglycaemia duration is longer at night and is inversely correlated with the level of glycated haemoglobin (HbA1c), a new study reports.
4 days ago
Podcast: Dr Shamir Mehta briefly discusses the clinical impact of findings from the COMPLETE trial
3 days ago
Podcast: Prof Derek Chew explains the importance of a 1-hour troponin T protocol in suspected ACS as discussed in the RAPID-TnT trial
4 days ago
Sodium-glucose transport protein 2 (SGLT2) inhibitors exert a putative epigenetic regulation of the protecting cardiovascular effect, reports a study, adding that dapagliflozin may protect the kidneys by preserving renal vasodilating capacity.