Most Read Articles
11 Aug 2020
During the Allergic Rhinitis (AR) Boot Camp held in conjunction with the Bayer Pharmacist Congress 2020, Professor Dr Baharudin Abdullah discussed the management of AR in the primary care setting and the importance of using patient profiles to guide the choice of antihistamines.
Elaine Soliven, 2 days ago
Adding mepolizumab to standard of care treatment significantly reduces nasal polyp size and obstruction in adults with chronic rhinosinusitis with nasal polyps (CRSwNP), according to the SYNAPSE* study presented at ERS 2020.
4 days ago
OZEMPIC – Semaglutide 1.34 mg/mL soln for inj
Audrey Abella, 11 Sep 2020
A prasugrel de-escalation strategy significantly reduced the risk of NACE* and bleeding events in patients with ACS** after PCI*** compared with the conventional strategy, results of the HOST-REDUCE-POLYTECH-ACS# trial have shown.

Sorafenib plus hepatic arterial infusion chemo safe, effective in advanced HCC

03 Sep 2020

Treatment with sorafenib plus hepatic arterial infusion chemotherapy (SoraHAIC) for advanced hepatocellular carcinoma (HCC) has been shown to be safe and effective in a recent study.

The investigators performed a systematic search of The Cochrane Library, PubMed, and Embase databases, and divided the major outcomes in patients with advanced HCC into SoraHAIC group and sorafenib group, which included overall response rate, overall survival, progressive disease, and adverse events.

Five studies involving a total of 726 patients were included in the meta-analysis, which showed significantly more improvement with SoraHAIC than sorafenib alone in overall response rate (risk ratio [RR], 3.08, 95 percent confidence interval [CI], 1.38–6.89; p=0.006) and complete response (RR, 5.84, 95 percent CI, 1.85–18.45; p=0.003).

Of note, the combination therapy significantly improved the median overall survival as compared with sorafenib alone (hazard ratio, 0.59, 95 percent CI, 0.35–1.00; p=0.05). However, the SoraHAIC group had a significantly greater risk of adverse events, such as anaemia, neutropaenia, and thrombocytopaenia, than the sorafenib monotherapy group (pall<0.05).

“[A]dditional large-scale randomized controlled trials are needed to further investigate the clinical benefit [of SoraHAIC],” the investigators said.

In an earlier study, SoraHAIC also improved overall survival and had acceptable toxic effects compared with sorafenib alone in patients with hepatocellular carcinoma and portal vein invasion. The median overall survival was 13.37 months (95 percent CI, 10.27–16.46) in the SoraHAIC group compared with 7.13 months (95 percent CI, 6.28–7.98) in the sorafenib monotherapy group (HR, 0.35, 95 percent CI, 0.26–0.48; p<0.001). [JAMA Oncol 2019;5:953-960]

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Most Read Articles
11 Aug 2020
During the Allergic Rhinitis (AR) Boot Camp held in conjunction with the Bayer Pharmacist Congress 2020, Professor Dr Baharudin Abdullah discussed the management of AR in the primary care setting and the importance of using patient profiles to guide the choice of antihistamines.
Elaine Soliven, 2 days ago
Adding mepolizumab to standard of care treatment significantly reduces nasal polyp size and obstruction in adults with chronic rhinosinusitis with nasal polyps (CRSwNP), according to the SYNAPSE* study presented at ERS 2020.
4 days ago
OZEMPIC – Semaglutide 1.34 mg/mL soln for inj
Audrey Abella, 11 Sep 2020
A prasugrel de-escalation strategy significantly reduced the risk of NACE* and bleeding events in patients with ACS** after PCI*** compared with the conventional strategy, results of the HOST-REDUCE-POLYTECH-ACS# trial have shown.