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Dr. Joseph Delano Fule Robles, 23 Jan 2019

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Sofosbuvir-velpatasvir combo safe, effective for HCV patients with end-stage renal disease

05 Oct 2019

The combination of sofosbuvir and velpatasvir is safe and effective for the treatment of hepatitis C virus (HCV) in patients with end-stage renal disease (ESRD) undergoing haemodialysis, a study has shown.

Fifty-nine HCV patients (mean age, 60 years; 59 percent male) undergoing haemodialysis or peritoneal dialysis of ESRD were given open-label sofosbuvir/velpatasvir (400 mg/100 mg) once daily for 12 weeks. The primary efficacy endpoint was the proportion of participants reaching sustained virological response 12 weeks after the treatment was discontinued (SVR12). Discontinuation due to adverse events was the primary safety endpoint.

Almost all patients achieved SVR12 (95 percent; n=56). Most of the patients who achieved the primary efficacy endpoint had drug adherence rates of at least 90 percent. Those who fell short of SVR12 had adherence rates of <90 percent; one patient died of suicide after achieving viral suppression 79 days after treatment.

Adverse events were also fairly common, with 80 percent of the study population reporting at least one episode. Most were mild or moderate in severity.

The most common side effects were headache (17 percent), fatigue (14 percent), nausea (14 percent), vomiting (14 percent) and insomnia (10 percent). Eleven patients (19 percent) experienced serious adverse events, though none were deemed to be related to the study treatment. There were no discontinuations due to adverse events.

Aside from the suicide, one other death occurred due to metastatic lung cancer 111 days after completing the study.

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Most Read Articles
Jairia Dela Cruz, 30 Aug 2019
Infection with hepatitis B virus (HBV) does not appear to independently affect pregnancy outcomes, although it contributes to prolonged infertility, higher odds of secondary infertility, ovulatory disorders and reduced implantation rate, a study has found.
Dr. Joseph Delano Fule Robles, 23 Jan 2019

Scientists from the Department of Microbiology, University of Hong Kong (HKU) recently discovered a compound with broad antiviral activity against viruses causing Middle East Respiratory Syndrome (MERS), avian flu (H7N9), severe acute respiratory syndrome (SARS) and Zika fever.