Most Read Articles
27 Jan 2018
There is an over-representation of women in published reports of celecoxib drug-induced liver injury (DILI), according to a recent study. Latency has been shown to be short (<3 months) in most patients, but some of them may present with DILI after prolonged use of celecoxib.
22 Mar 2016
A recent study showed that routine use of alpha galactosidase (AG) has no benefit in irritable bowel syndrome (IBS) patients.
15 Nov 2017
Both hatha yoga and a low-FODMAP (Fermentable, Oligo-, Di-, Monosaccharides and Polyol) diet can alleviate gastrointestinal symptoms, as well as improve a range of other psychological and physiological health parameters, in patients with irritable bowel syndrome (IBS), a study has shown.
Rachel Soon, 14 Dec 2016

More well-designed studies are needed to confirm the benefits of various probiotics currently promoted for gut health, according to experts.

Sofosbuvir plus simeprevir or daclatasvir highly effective in hepatitis C genotype 4 infection

02 May 2018
Authorities in Malaysia have approved a compulsory license for Hepatitis C treatment, which allows for cheaper generic medication to be produced without the drug patent holder’s consent.

The combination of sofosbuvir with either simeprevir or daclatasvir is safe and very effective for the treatment of hepatitis C virus (HCV)-genotype 4 (GT4) infection, reports a new study. In addition, treatment response is not affected by cirrhosis and failure of prior interferon-based therapy.

This real-life, prospective, observational study evaluated HCV-GT4 patients (n=96; mean age, 49±14.6 years; 59.4 percent men) in two groups based on the 12-week treatment regimen they received. Patients in group 1 (n=56) were administered sofosbuvir and simeprevir±ribavirin, while those in group 2 (n=40) received sofosbuvir and daclatasvir±ribavirin.

Sustained virologic response 12 weeks after the end of treatment (SVR12) was the primary efficacy endpoint, and the primary safety endpoint was drug discontinuation or occurrence of grade 3 or 4 adverse events.

Cirrhosis was present in 53.6 percent of patients in group 1 and 35.0 percent in group 2. On the other hand, 27 patients (48.3 percent) and 21 patients (52.5 percent) in groups 1 and 2, respectively, had failed prior interferon-based treatment.

The median pretreatment HCV-RNA log10 was 6.1 (3.6–7.0) IU/mL in group 1 and 6.0 3.6–7.2 IU/mL in group 2. Seventeen patients (30.4 percent) in group 1 and two patients (5 percent) in group 2 received ribavirin. All patients (100 percent) achieved SVR12.

Although adverse events (grade 1 and 2) were reported in 32 percent of patients, none discontinued treatment. There was one death recorded in the simeprevir group, but it was not treatment-related.

“The combination of sofosbuvir with simeprevir or daclatasvir is very effective in treating HCV infection, particularly genotype 1. However, the data on GT4 are very limited,” the authors said. This study supports the efficacy of these combination treatments on HCV-GT4.

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Most Read Articles
27 Jan 2018
There is an over-representation of women in published reports of celecoxib drug-induced liver injury (DILI), according to a recent study. Latency has been shown to be short (<3 months) in most patients, but some of them may present with DILI after prolonged use of celecoxib.
22 Mar 2016
A recent study showed that routine use of alpha galactosidase (AG) has no benefit in irritable bowel syndrome (IBS) patients.
15 Nov 2017
Both hatha yoga and a low-FODMAP (Fermentable, Oligo-, Di-, Monosaccharides and Polyol) diet can alleviate gastrointestinal symptoms, as well as improve a range of other psychological and physiological health parameters, in patients with irritable bowel syndrome (IBS), a study has shown.
Rachel Soon, 14 Dec 2016

More well-designed studies are needed to confirm the benefits of various probiotics currently promoted for gut health, according to experts.