Most Read Articles
17 Dec 2018
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Sofosbuvir plus simeprevir or daclatasvir highly effective in hepatitis C genotype 4 infection

02 May 2018
Authorities in Malaysia have approved a compulsory license for Hepatitis C treatment, which allows for cheaper generic medication to be produced without the drug patent holder’s consent.

The combination of sofosbuvir with either simeprevir or daclatasvir is safe and very effective for the treatment of hepatitis C virus (HCV)-genotype 4 (GT4) infection, reports a new study. In addition, treatment response is not affected by cirrhosis and failure of prior interferon-based therapy.

This real-life, prospective, observational study evaluated HCV-GT4 patients (n=96; mean age, 49±14.6 years; 59.4 percent men) in two groups based on the 12-week treatment regimen they received. Patients in group 1 (n=56) were administered sofosbuvir and simeprevir±ribavirin, while those in group 2 (n=40) received sofosbuvir and daclatasvir±ribavirin.

Sustained virologic response 12 weeks after the end of treatment (SVR12) was the primary efficacy endpoint, and the primary safety endpoint was drug discontinuation or occurrence of grade 3 or 4 adverse events.

Cirrhosis was present in 53.6 percent of patients in group 1 and 35.0 percent in group 2. On the other hand, 27 patients (48.3 percent) and 21 patients (52.5 percent) in groups 1 and 2, respectively, had failed prior interferon-based treatment.

The median pretreatment HCV-RNA log10 was 6.1 (3.6–7.0) IU/mL in group 1 and 6.0 3.6–7.2 IU/mL in group 2. Seventeen patients (30.4 percent) in group 1 and two patients (5 percent) in group 2 received ribavirin. All patients (100 percent) achieved SVR12.

Although adverse events (grade 1 and 2) were reported in 32 percent of patients, none discontinued treatment. There was one death recorded in the simeprevir group, but it was not treatment-related.

“The combination of sofosbuvir with simeprevir or daclatasvir is very effective in treating HCV infection, particularly genotype 1. However, the data on GT4 are very limited,” the authors said. This study supports the efficacy of these combination treatments on HCV-GT4.

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Most Read Articles
17 Dec 2018
Modifiable lifestyle behaviours, such as diet and exercise, significantly affect the risk of colorectal cancer (CRC), a recent study has shown.
Roshini Claire Anthony, 21 Apr 2016
Twenty-year survival is possible in almost 80 percent of children who had a liver transplant and were given cyclosporine as their primary immunosuppressive regimen, according to a study presented at the annual meeting of the European Association for the Study of the Liver (EASL) International Liver Congress™ (ILC) 2016 in Barcelona, Spain.
Pearl Toh, 10 Jan 2019
Adding a proton-pump inhibitor (PPI) to anticoagulant therapy significantly lowers the risk of hospitalizations for upper gastrointestinal (GI) tract bleeding associated with anticoagulant use, a study finds.
6 days ago
Among patients with inflammatory bowel disease (IBD), older age at the time of IBD diagnosis and longer disease duration are associated with a heightened risk of developing colitis-associated neoplasia, a study has found.