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Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
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Sofosbuvir-based DAAs tied to declining eGFR in HCV patients

02 May 2020

Using sofosbuvir (SOF)-based direct antiviral agents (DAAs) may accelerate the decline of estimated glomerular filtration rate (eGFR) in patients with chronic hepatitis C virus (HCV) infections, reports a new study.

Researchers prospectively assessed 481 HCV patients with compensated liver diseases. EGFR was 30 mL/min/1.73m2 at baseline, and its change over time was assessed until off-therapy week 24 using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation.

Most of the participants were on SOF-based DAAs (n=308; mean age, 55±14 years; 58 percent male), while the rest were receiving SOF-free therapies (n=173; mean age, 59±12 years; 52 percent male). Baseline eGFR and CKD stages were comparable between treatment groups.

Patients on SOF-based DAAs saw more significant eGFR declines from baseline to on-treatment week 12 than their counterparts on SOF-free treatments (p<0.001). This trend persisted until off-therapy week 24 (p=0.001).

Multivariate analysis found that from baseline to off-treatment week 24, the use of SOF-based DAAs led to an adjusted eGFR slope coefficient difference of –0.33 mL/min/1.73m2/month (95 percent confidence interval [CI], –0.49 to –0.17; p<0.001).

Breaking it down further, the researchers saw that eGFR declined during SOF-based DAA treatment (slope coefficient difference, –1.24 mL/min/1.73m2/month, 95 percent CI, –1.35 to –1.13; p<0.001) and recovered off-treatment (slope coefficient difference, 0.33 mL/min/1.73m2/month, 95 percent CI, 0.26 to 0.40; p<0.001).

“By repeated eGFR assessment, we found that patients receiving SOF-based DAAs had a quadratic trend with on-treatment worsening and off-therapy improving eGFR,” the researchers said.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
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