Most Read Articles
6 days ago
Slideshow: Highlights from the Asian Pacific Society of Cardiology 2019 Congress
Tristan Manalac, 22 Nov 2018
Initial treatment with endovascular therapy results in better amputation-free survival in patients with critical limb ischaemia compared with open surgical bypass, according to a study presented at the American Heart Association Scientific Session 2018 (AHA 2018), held in Chicago, Illinois.
04 Jun 2019
The addition of alirocumab to intensive statin therapy appears to cut the risk of death following acute coronary syndrome, especially if treatment is sustained for at least 3 years, if baseline low-density lipoprotein cholesterol (LDL-C) is ≥100 mg/dL or if achieved LDL-C is low, according to data from the ODYSSEY OUTCOMES.
6 days ago
Use of aspirin for primary prevention of cardiovascular (CV) events leads to lower nonfatal ischaemic events but significantly greater nonfatal bleeding events, a recent study has shown.

Sodium intake reduction may help improve BP in hypertensive individuals

19 May 2019

A recent study shows evidence of an association between blood pressure (BP) and sodium reduction (SR), with hypertensive individuals demonstrating a clinically significant drop in BP with SR.

A linear dose-response relation was observed between SR and BP in study groups with mean BP above the 75th percentile (131/78 mm Hg). For systolic blood pressure (SBP), there was a dose-response relation of –7.7 mm Hg/100 mmol SR (95 percent CI, –10.4 to –5.0). For diastolic blood pressure (DBP), the dose-response relation was –3.0 mm Hg/100 mmol SR (–4.6 to –1.4).

On the other hand, there was a weak association between SR and BP in study groups with mean BP ≤131/78 mm Hg. The dose-response relation was –1.46 mm Hg/100 mmol SR (–2.7 to –0.20) for SBP and –0.07 mm Hg/100 mmol SR (–1.5 to 1.4) for DBP.

“Only study groups with a BP in the highest 25th percentile of the population showed a clinically significant drop in BP with SR,” the authors said. “The policy of lowering dietary sodium intake in the general population may need to be reframed to target patients with hypertension.”

In this meta-regression analysis, the dose-response relations between SR and BP were estimated in study groups with mean BP above or below the 75th percentile of the general population. The authors conducted a literature search from 1 January 1946 to 11 April 2018 and identified 133 randomized controlled trials allocating healthy or hypertensive individuals to SR or usual sodium intake.

The authors also performed multivariable regression analyses of the mean SR vs the mean BP effect adjusted for effect modifiers.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Cardiology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
6 days ago
Slideshow: Highlights from the Asian Pacific Society of Cardiology 2019 Congress
Tristan Manalac, 22 Nov 2018
Initial treatment with endovascular therapy results in better amputation-free survival in patients with critical limb ischaemia compared with open surgical bypass, according to a study presented at the American Heart Association Scientific Session 2018 (AHA 2018), held in Chicago, Illinois.
04 Jun 2019
The addition of alirocumab to intensive statin therapy appears to cut the risk of death following acute coronary syndrome, especially if treatment is sustained for at least 3 years, if baseline low-density lipoprotein cholesterol (LDL-C) is ≥100 mg/dL or if achieved LDL-C is low, according to data from the ODYSSEY OUTCOMES.
6 days ago
Use of aspirin for primary prevention of cardiovascular (CV) events leads to lower nonfatal ischaemic events but significantly greater nonfatal bleeding events, a recent study has shown.