Most Read Articles
Dr. Joseph Delano Fule Robles, 14 Nov 2017

A recent study conducted by The University of Hong Kong (HKU) revealed that long-term use of proton pump inhibitors (PPIs) is associated with a significantly increased risk of gastric cancer even in patients who have had Helicobacter pylori eradicated. 

14 Nov 2017
The 5-year survival rates for human papillomavirus (HPV)-associated cancers vary greatly according to age and race, with Caucasians and younger patients tending to have better survival, according to a recent US study.
6 days ago
Both hatha yoga and a low-FODMAP (Fermentable, Oligo-, Di-, Monosaccharides and Polyol) diet can alleviate gastrointestinal symptoms, as well as improve a range of other psychological and physiological health parameters, in patients with irritable bowel syndrome (IBS), a study has shown.
6 days ago
Men with breast cancer have tumours that are typically of the human epidermal growth factor receptor 2-negative Luminal B subtype and positive for oestrogen receptor, progesterone receptor and androgen receptor, according to the results of the EORTC 10085/TBCRC/BIG/NABCG International Male Breast Cancer Program study.

Sodium bicarbonate after heart surgery may harm kidneys in patients with IE

27 Jan 2017
Contamination of heater-cooler devices puts patients who undergo open-heart surgery at high risk

Administration of sodium bicarbonate appears to have no beneficial effects on patients with infective endocarditis (IE) undergoing heart surgery; instead, it may have potentially detrimental effects on renal function as demonstrated by increased postoperative peak serum creatinine (SCr) levels, according to a study.

The randomized, placebo-controlled clinical trial involved 70 patients aged between 20 and 80 years who were assigned to receive either sodium bicarbonate (n=35) or sodium chloride (n=35) as control. Sodium bicarbonate was given as a 0.5 mmol/kg loading dose for 1 hour with induction of anaethesia followed by a 0.15 mmol/kg/h infusion for 23 hours, whereas sodium chloride was similarly administered in equivalent volumes.

The primary outcome was the difference in SCr levels during the first 48 hours after surgery, with a difference in SCr >0.3 mg/dL considered clinically significant based on the Acute Kidney Injury Network criteria. The incidence of acute kidney injury, SCr level, estimated glomerular filtration rate and major morbidity endpoints were assessed postoperatively.

Secondary outcomes included the incidence of postoperative acute kidney injury (AKI), electrolyte abnormalities, major morbidity endpoints (permanent stroke, haemostatic re-exploration, AKI, prolonged ventilator care and deep sternal wound infection), ICU and hospital length of stay, and in-hospital mortality. Changes in eGFR were also assessed.

There were no differences observed between groups with regard to peak SCr during the first 48 hours postoperatively and the incidence of AKI. Compared with the control group, there was a greater postoperative increase in SCr above baseline in the bicarbonate group on postoperative day 2 (0.21 mg/dL vs 0.06 mg/dL; p=0.028) and postoperative day 5 (0.23 mg/dL vs 0.06 mg/dL, p=0.017). Postoperative renal and nonrenal function outcomes were similar between groups.
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Most Read Articles
Dr. Joseph Delano Fule Robles, 14 Nov 2017

A recent study conducted by The University of Hong Kong (HKU) revealed that long-term use of proton pump inhibitors (PPIs) is associated with a significantly increased risk of gastric cancer even in patients who have had Helicobacter pylori eradicated. 

14 Nov 2017
The 5-year survival rates for human papillomavirus (HPV)-associated cancers vary greatly according to age and race, with Caucasians and younger patients tending to have better survival, according to a recent US study.
6 days ago
Both hatha yoga and a low-FODMAP (Fermentable, Oligo-, Di-, Monosaccharides and Polyol) diet can alleviate gastrointestinal symptoms, as well as improve a range of other psychological and physiological health parameters, in patients with irritable bowel syndrome (IBS), a study has shown.
6 days ago
Men with breast cancer have tumours that are typically of the human epidermal growth factor receptor 2-negative Luminal B subtype and positive for oestrogen receptor, progesterone receptor and androgen receptor, according to the results of the EORTC 10085/TBCRC/BIG/NABCG International Male Breast Cancer Program study.