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Jackey Suen, 08 Oct 2018

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Social, psychological, physical factors affect HRQOL in elderly cancer patients

27 Dec 2017
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Persistent symptoms, comorbidities, and financial challenges appear to be important factors affecting health-related quality of life (HRQOL) in geriatric cancer patients, a recent study has shown.

Researchers measured the HRQOL of 1,457 elderly cancer patients (mean age 74.2±7.3 years; 51 percent female), who had mean Mental Component Summary (MCS) and Physical Component Survey (PCS) scores of 53.1±9.6 and 42.3±10.7 points, respectively.

In preliminary analyses, PCS scores were significantly associated with symptom severity and physical support needs, while MCS scores were tied to symptom severity and financial hardships.

However, when researchers used linear models, they found that physical support needs, physical activity score, comorbidity scores, and symptom severity were the most relevant factors for the PCS scores, indicating that social, psychological, and physical domains all affect PCS.

In comparison, emotional support needs, symptom severity scores, and the number of financial hardship events were found to be the most relevant variables for MCS scores. This also shows that MCS is affected by physical, social, and psychological domains.

In terms of symptoms, PCS scores were most strongly affected by drowsiness, disturbed sleep, pain, and fatigue. MCS scores, on the other hand, were associated with lack of appetite, disturbed sleep, problems remembering things, and fatigue.

“The results of the current study suggest that to improve the HRQOL of older cancer survivors, the approach to survivorship care should include the appropriate management of symptoms and comorbid conditions and the promotion of healthy lifestyles,” said researchers.

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Most Read Articles
Jackey Suen, 08 Oct 2018

Adding pertuzumab to trastuzumab plus an aromatase inhibitor (AI) improves progression-free survival (PFS) in patients with HER2-positive metastatic or locally advanced breast cancer, the phase II PERTAIN study has shown.

Jackey Suen, 09 Oct 2018

LCL161, an experimental inhibitor of apoptosis (IAP) protein antagonist, is shown to improve pathologic complete response (pCR) when added to paclitaxel in selected patients with localized triple-negative breast cancer (TNBC) in neoadjuvant settings.

01 Dec 2015
Colchine use in male Taiwanese patients with gout is associated with substantially reduced risk for cancer, as shown in a 12-year cohort study.