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Smoking ups risk of abdominal aortic aneurysm

17 Oct 2018
Smoking is the single most important risk factor for cancer.

Smoking appears to increase the risk of abdominal aortic aneurysm, particularly among current smokers, reports a recent meta-analysis. The risk appears to taper with a lower number of cigarette sticks smoked per day.

A total of 23 studies were eligible for inclusion in the analysis, most of which (n=20 studies) were of current smokers (n=8,901 smokers). Fifteen studies included 7,824 former smokers, while 18 studies involved 8,448 ever smokers.

Compared with never smokers, current smokers were significantly more likely to develop abdominal aortic aneurysm (relative risk [RR], 4.87; 95 percent CI, 3.93–6.02). There was significant heterogeneity among the studies (p<0.0001).

Similar risk elevations were observed for former smokers (RR, 2.10; 1.76–2.50) and ever smokers (RR, 3.28; 2.60–4.15), though of lower magnitudes. In both cases, heterogeneity among studies were likewise significant (p<0.0001). No evidence of publication bias was reported for all three analyses, according to Egger’s test.

A pooled analysis of seven studies showed that every 10-stick increment in daily use was associated with a significant increase in the associated risk (RR, 1.87; 1.45–2.40). The correlation was significantly nonlinear (p<0.0001), such that use of 15–20 sticks per day was associated with the strongest increase in risk, while use beyond 20 sticks had no further effect.

A similar effect was observed for the number of pack-years: Each 10-pack-year increment was associated with a significant rise in the risk of abdominal aortic aneurysms (RR, 1.78; 1.54–2.06).

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Most Read Articles
Roshini Claire Anthony, 5 days ago

Individuals with moderate-to-severe plaque psoriasis may reap better long-term improvements in the severity of their condition when treated with guselkumab over secukinumab, according to findings of the phase III ECLIPSE* trial presented at the recent Inflammatory Skin Disease Summit (ISDS 2018) held in Vienna, Austria.

Jairia Dela Cruz, 11 Jan 2019
Use of standard-dose aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) appears to confer protection against the risk of endometrial cancer in overweight and obese women, according to a meta-analysis.
4 days ago
Discontinuing the use of tyrosine kinase inhibitors (TKIs) in the treatment of patients with chronic myeloid leukaemia appears to be feasible in real-life clinical practice in the context of close molecular monitoring, a study reports.
5 days ago
There appears to be no clear link between pornography use, even at problematic levels, and erectile dysfunction, a recent US study has shown.