Most Read Articles
28 Jun 2019
Whole-brain radiotherapy confers a slight survival benefit for elderly small cell lung cancer patients with brain metastasis unfit for chemotherapy, a recent study has shown.
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High-protein intake during the first 28 days after birth appears to improve weight growth in very preterm infants, a recent study has found. No such effect is reported for brain outcomes.
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A large prospective Chinese cohort study has found long sleep duration (≥9 hours/night) and long mid-day napping (>90 minutes) to be significantly associated with a higher risk of ischaemic stroke.

Smoking compromises functional outcomes after acute ischaemic stroke

09 Jan 2020

Acute ischaemic stroke patients who are current or recent smokers are at greater odds of having unfavourable functional outcomes 3 months after the index event, a study has found.

Researchers looked at 10,825 patients (mean age, 70.2 years; 37.0 percent female) with acute ischaemic stroke who had been independent before stroke onset. Of the patients, 4,396 (42.7 percent) had never smoked (nonsmokers), 3,328 (32.4 percent) were former smokers and 2,561 (24.9 percent) were current smokers.

Multivariable logistic regression analysis showed that compared with nonsmokers, current but not former smokers had poorer functional outcome (modified Rankin Scale score ≥2) at 3 months. The corresponding odds ratios (ORs) were 1.29 (95 percent confidence interval [CI], 1.11–1.49) and 1.05 (95 percent CI, 0.92–1.21).

Among the former smokers, those who quit smoking within 2 years of stroke onset had a higher likelihood of having poor functional outcome at 3 months relative to nonsmokers (OR, 1.75, 95 percent CI, 1.15–2.66). Of note, the odds of poor functional outcome tended to increase with greater number of daily cigarettes used (p-trend=0.002).

The same pattern of associations was observed for functional dependence (modified Rankin Scale score 2–5).

Given the findings, smoking cessation should be urged not only from the standpoint of averting the development or recurrence of stroke but also to improve poststroke functional restoration and outcome, according to the researchers.

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Most Read Articles
28 Jun 2019
Whole-brain radiotherapy confers a slight survival benefit for elderly small cell lung cancer patients with brain metastasis unfit for chemotherapy, a recent study has shown.
Natalia Reoutova, 27 Jun 2019

Adults who developed multiple sclerosis (MS) in childhood or adolescence had significantly higher odds of impairment and greater decline over time in information-processing efficiency than adults who developed MS later in life, independent of age or disease duration, a large population-based longitudinal cohort study has shown.

30 Dec 2019
High-protein intake during the first 28 days after birth appears to improve weight growth in very preterm infants, a recent study has found. No such effect is reported for brain outcomes.
Natalia Reoutova, 07 Jan 2020

A large prospective Chinese cohort study has found long sleep duration (≥9 hours/night) and long mid-day napping (>90 minutes) to be significantly associated with a higher risk of ischaemic stroke.