Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.

Smoking at home, during teenage years up risk of death from bladder, kidney cancers

19 Nov 2019

Smoking intensity is associated with mortality from genitourinary malignancies, according to a nationally representative study. Moreover, the risk of death from bladder and kidney cancers is significantly higher among individuals who started smoking at a younger age and those who smoke at home.

More participants who had ever smoked died compared to those who had never smoked (5.6 percent vs 3.1 percent; p<0.0001) during a 5-year follow-up. Smokers comprised the majority of those who died of bladder (62 percent), kidney (58 percent) and prostate cancers (62 percent).

Multivariable analysis revealed an association between ever smoking and mortality from bladder (hazard ratio [HR], 1.92, 95 percent confidence interval [CI], 1.25–2.97) and kidney cancer (HR, 1.54, 95 percent CI, 1.01–2.34).

In addition, starting to smoke during teenage years and smoking at home correlated with bladder cancer-specific mortality (HR, 2.14, 95 percent CI, 1.28–3.56 and HR, 2.99, 95 percent CI, 1.34–6.65) and kidney cancer-specific mortality (HR, 1.65, 95 percent CI, 1.03–2.66 and HR, 2.84, 95 percent CI, 1.54–5.23, respectively).

On the other hand, only everyday smoking correlated with a higher risk of prostate cancer mortality (HR, 1.81, 95 percent CI, 1.30–2.53).

This study included 493,282 participants in the National Longitudinal Mortality Study who provided detailed tobacco information from 1993 to 2005. Death from bladder, kidney or prostate cancer was the primary outcome. Cause of death was determined from death certificates.

Smoking parameters analysed were as follows: smoking status at the time of the survey, age at the start of smoking and home smoking rules. The associations of these parameters with bladder, kidney and prostate cancer-specific mortality were evaluated using multivariable Cox regression models.

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Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.