Smoking, alcohol use implicated in sessile serrated polyp prevalence in young adults
Smoking and alcohol consumption are associated with increased prevalence of any and large sessile serrated polyps (SSPs), with smoking cessation exerting a protective effect on the risk of SSPs, a study has found.
The cross-sectional study included 13,618 asymptomatic individuals aged 30–49 years and 17,999 of those aged 50–75 years. Researchers examined risk factors for SSP via multivariable analyses of clinical data that included cigarette smoking and alcohol intake.
SSPs were detected in 686 individuals (2.2 percent) overall, and none had serrated polyposis syndrome. The prevalence of SSPs was similar in the younger and older age groups (2.0 percent vs 2.3 percent; p=0.119).
In the younger age group, 40.7 percent of individuals (112 of 275) had large SSPs (≥10 mm). Longer smoking duration (≥20 pack-years) significantly predicted overall SSPs (odds ratio [OR], 1.87, 95 percent CI, 1.17–2.99) and large SSPs (OR, 3.03, 1.62–5.66). With respect to the anatomic location of SSPs, ≥20 pack-years of smoking showed a stronger association with distal SSPs (OR, 2.71, 1.27–5.77) than with proximal SSPs (OR, 1.60, 1.00–2.54).
Cessation of smoking for ≥5 years reduced the risks of overall SSPs (OR, 0.49, 0.28–0.86) and large SSPs (OR, 0.23, 0.10–0.54).
Meanwhile, heavy drinking was associated with overall SSPs (OR, 1.78, 1.10–2.90). Regardless of the amount and frequency, alcohol consumption was related to large SSPs. These findings were similar among individuals in the older age group.
The present data highlight the potential of early lifestyle modification in the primary prevention of SSPs in young adults, the researchers said.