Most Read Articles
14 Feb 2020
Chronic pancreatitis patients taking antioxidants (AO) supplementation show a sustained increase in blood levels of AO, but no additional benefit is seen on endocrine and exocrine functions, markers of fibrosis, oxidative stress (OS) and inflammation, nutritional status, pain, and quality of life (QOL) when compared with those on placebo, according to a study.
Jairia Dela Cruz, 19 Feb 2020
A diet low in fat and high in fibre seems well tolerated in patients with ulcerative colitis, not contributing to increased inflammation while significantly increasing populations of Faecalibacterium prausnitzii, according to a study presented at the 2020 Crohn's & Colitis Congress.
21 Jan 2018
The Reflux Improvement and Monitoring (TRIM) programme for the management of patients with obesity and gastroesophageal reflux disease (GERD) appears to produce improvements in patient-reported symptom severity, quality of life and weight, a study reports.
Pearl Toh, 14 Feb 2020
Donor selection for faecal microbiota transplant (FMT) can make a difference to maintenance of long-term remission in patients with ulcerative colitis (UC), reveals a study presented at the 2020 Crohn's & Colitis Congress (CCC).

Small intestinal bacterial overgrowth linked to irritable bowel syndrome

15 Feb 2020

An association appears to exist between irritable bowel syndrome (IBS) and small intestinal bacterial overgrowth (SIBO), suggest the results of a systematic review and meta-analysis. However, the overall quality of evidence is low.

“This is mainly due to substantial ‘clinical heterogeneity’ due to lack of uniform selection criteria for cases and controls and limited sensitivity and specificity of the available diagnostic tests,” the investigators said.

Studies reporting SIBO prevalence in IBS patients were identified through electronic database searches up to December 2018. The investigators calculated prevalence rates, odds ratios (ORs) and 95 percent confidence intervals (CIs) of SIBO in IBS patients.

Twenty-five studies comprising 3,192 patients with IBS and 3,320 controls met the eligibility criteria. SIBO prevalence was significantly greater in IBS patients compared with controls (OR, 3.7, 95 percent CI, 2.3–6.0). In studies with only healthy controls, SIBO in IBS patients showed a much higher OR at 4.9 (95 percent CI, 2.8–8.6).

SIBO prevalence diagnosed by breath test remained higher in IBS patients (35.5 percent, 95 percent CI, 33.6–37.4) than in controls (29.7 percent, 95 percent CI, 27.6–31.8).

In culture-based studies, SIBO prevalence was 13.9 percent (95 percent CI, 11.5–16.4) in IBS patients and 5.0 percent (95 percent CI, 3.9–6.2) in controls with a cutoff value of 105 colony-forming units per millilitre compared with 33.5 percent (95 percent CI, 30.1–36.9) in IBS patients and 8.2 percent (95 percent CI, 6.8–9.6) in controls with a cutoff value of 103 colony-forming unit per millilitre.

SIBO prevalence was much greater in both patients with IBS (3.6-fold) and controls (7.6-fold) on lactulose vs glucose breath tests. Difference was comparable when lactulose breath test was compared with culture methods.

SIBO in patients with IBS-diarrhoea vs IBS-constipation had an OR of 1.86 (95 percent CI, 1.83–2.8). Methane-positive breath tests were significantly more prevalent in IBS-constipation vs IBS-diarrhoea (OR, 2.3, 95 percent CI, 1.2–4.2).

In addition, use of proton pump inhibitors did not correlate with SIBO in patients with IBS (OR, 0.8, 95 percent, 0.5–1.5; p=0.55).

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Most Read Articles
14 Feb 2020
Chronic pancreatitis patients taking antioxidants (AO) supplementation show a sustained increase in blood levels of AO, but no additional benefit is seen on endocrine and exocrine functions, markers of fibrosis, oxidative stress (OS) and inflammation, nutritional status, pain, and quality of life (QOL) when compared with those on placebo, according to a study.
Jairia Dela Cruz, 19 Feb 2020
A diet low in fat and high in fibre seems well tolerated in patients with ulcerative colitis, not contributing to increased inflammation while significantly increasing populations of Faecalibacterium prausnitzii, according to a study presented at the 2020 Crohn's & Colitis Congress.
21 Jan 2018
The Reflux Improvement and Monitoring (TRIM) programme for the management of patients with obesity and gastroesophageal reflux disease (GERD) appears to produce improvements in patient-reported symptom severity, quality of life and weight, a study reports.
Pearl Toh, 14 Feb 2020
Donor selection for faecal microbiota transplant (FMT) can make a difference to maintenance of long-term remission in patients with ulcerative colitis (UC), reveals a study presented at the 2020 Crohn's & Colitis Congress (CCC).