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Slow gait speed predicts mortality after TAVI

07 Jun 2020

Slow gait speed and an inability to walk may predict mortality risk after transcatheter aortic valve implantation (TAVI), a recent meta-analysis has found.

Researchers retrieved 12 eligible studies from the databases of PubMed and Web of Science. Seven studies were based on distance-limited walk test, while others measured gait speed according to time-based walk tests. Sample sizes ranged from 89 to 21,661 while follow-up lengths ranged from 30 days to 4 years.

Pooled analysis of all risk estimates showed that slow walkers were at a significantly greater risk of mortality (primary meta-analysis; odds/hazard ratio [OR/HR], 2.38, 95 percent confidence interval [CI], 1.63–3.47; p<0.00001). Being unable to walk had a similar effect (OR/HR, 1.75, 95 percent CI, 1.12–2.72; p=0.01).

Stratification according to the gait test used did reveal important differences. Slow gait, as measured by the 4- or 5-minute or 15-feet walk tests remained strongly and significantly correlated with mortality risk (HR, 2.83, 95 percent CI, 1.50–5.35; p<0.0001). A similar effect was seen when gait was measured using the 6-minute walk test (HR, 2.11, 95 percent CI, 1.37–3.24; p=0.0007). The difference in effect estimates between the two sub-analyses was not significant (p=0.45).

Similarly, sensitivity analysis confined to only those with 1-year follow-up (p<0.0001) and exclusion of those with unadjusted estimates (p=0.0002) did not significantly alter the effect of slow gait on mortality risk.

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Most Read Articles
3 days ago
Routinely used for treating cardiovascular diseases, statins have been shown to benefit other conditions, and new evidence suggests that using the drug at high intensity reduces the risk of hip or knee replacement, an effect that may be specific to rheumatoid arthritis.
Jairia Dela Cruz, 4 days ago
Following vegan and vegetarian diets, which offer plenty of what is good for health, has been reported to have a downside: an increased risk of depression and anxiety, especially for younger adults.
Pearl Toh, 29 Jun 2020
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
Roshini Claire Anthony, Yesterday

Upadacitinib may be a suitable treatment for patients with active psoriatic arthritis (PsA) who have insufficient response to non-biologic disease-modifying anti-rheumatic drugs (non-bDMARDs), according to results of the phase III SELECT-PsA-1* trial presented at EULAR 2020.