Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
Yesterday
Daily intake of cow’s milk formula in early life helps prevent the development of cow’s milk allergy later on without competing with breastfeeding, a recent study has found.

Slight changes in PSA warrant closer attention in nonmetastatic CRPC

02 Dec 2020
Prostate cancer is a silent killer. Many may not be aware of the illness until it is too late.

Men with nonmetastatic castration-resistant prostate cancer (nmCRPC) who have rapidly rising levels of prostate-specific antigen (PSA) see radiographic progression of their malignancy even without meeting the criteria set by the Prostate Cancer Working Group 2 (PCWG2), a recent study has shown.

Such radiographic evidence of cancer progression may indicate that any increase in PSA is worth further evaluation and closer monitoring.

Researchers conducted a posthoc, retrospective analysis of nmCRPC patients who had previously been randomized to receive enzalutamide or placebo. All participants were on antigen deprivation therapy (ADT). A total of 208 enzalutamide-treated patients showed PCWG2-defined PSA progression while 725 did not. In the placebo arm, 324 had PSA progression and 144 had no progression.

In both the enzalutamide and placebo arms, the metastasis-free survival (MFS) was shorter among patients who showed evidence of PSA progression; in men who had no such progression, median MFS was not reached. The risk of metastasis or death was likewise significantly aggravated among patients with PSA progression, but only in the enzalutamide arm (p<0.0001) and not among placebo controls.

However, even among participants who had no PSA progression, as defined by the PCWG2, some signals of radiographic progression were observed. Of the 725 enzalutamide-treated men without PSA progression, 10 percent (n=75) showed evidence of radiographic progression. This proportion was higher among placebo-treated patients at 26 percent (n=38).

Radiographic progression was nevertheless more prevalent among patients with PSA progression, reaching rates of over 50 percent in both the enzalutamide and placebo arms.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
Yesterday
Daily intake of cow’s milk formula in early life helps prevent the development of cow’s milk allergy later on without competing with breastfeeding, a recent study has found.