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01 Mar 2015
Red yeast rice extracts have been used in traditional medicine for centuries.1 In recent times, an extract from red yeast rice, Xuezhikang® (XZK), has been studied for its role in dyslipidaemia and cardiovascular disease. This review will look at some of the clinical trials that have done so.
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Sleep-trough morning BP surge associated with arterial stiffness

10 Jan 2017

There is a direct correlation between sleep-trough (ST) morning blood pressure surge (MBPS) and aortic stiffness in untreated hypertension, which is mediated by an elevated average real variability (AVR) of 24-hour systolic BP, a recent study has found.

Furthermore, the adverse effects of MBPS could be due to its relation with arterial stiffness, mediated by short-term SBP variability.

To describe the association between MBPS, short-term BP variability and arterial stiffness, researchers measured carotid-femoral pulse wave velocity (cf-PWV, SphygmoCor) and 24-hour ambulatory BP in 602 consecutive patients with untreated hypertension (mean age 48 years; 61 percent men; office BP, 149/93 mm Hg).

Using self-reported sleep and wake times, researchers defined MBPS as ST, prewaking and rising. They calculated short-term BP variability as weighted 24-hour SBP SD and AVR of 24-hour SBP, which is the average of absolute differences between consecutive SBP readings.

Both ST-MBPS (r=0.16; p<0.001) and rising MBPS (r=0.12; p=0.003) demonstrated a direct association with cf-PWF, while prewaking MBPS did not show such relation (r=0.06; p=0.14).

After adjusting for age, sex, height, office mean arterial pressure, heart rate and renal function, only ST-MBPS showed an independent correlation with cf-PWF (t=1.96; p=0.04). However, this association was lost after further adjustment for weighted 24-hour SBP SD (p=0.13) or ARV (p=0.24).

Finally, ARV was a significant mediator of the association between ST-MBPS and cf-PWF (p=0.003), according to researchers.

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Most Read Articles
01 Mar 2015
Red yeast rice extracts have been used in traditional medicine for centuries.1 In recent times, an extract from red yeast rice, Xuezhikang® (XZK), has been studied for its role in dyslipidaemia and cardiovascular disease. This review will look at some of the clinical trials that have done so.
13 Jun 2017
Both haemorrhagic and ischaemic stroke patients benefit similarly from a conventional therapy combined with robotic-assisted gait training (RAGT) intervention regimen, a new study shows.
30 Jun 2016
Perindopril can protect patients with paroxysmal atrial fibrillation (AF) from recurrence after radiofrequency catheter ablation, as stated in a study.
6 days ago
Enriching salt with both potassium and magnesium in the long term may provide additional benefits for stroke patient recovery from neurologic deficits, suggests a recent study involving Taiwanese patients.