Most Read Articles
Yesterday
Exposure to corticosteroids in patients with autoimmune hepatitis (AIH) appears to contribute to increased risks of cataract, diabetes and bone fractures, a study has found. Notably, the fracture risk is elevated at low doses, while the risk of adverse events overall is dose-dependent and is reversible.
6 days ago
In patients with atrial fibrillation (AF) and stable coronary artery disease (CAD), rivaroxaban monotherapy is noninferior to combination treatment with an antiplatelet therapy in terms of cutting the risk of cardiovascular events and mortality, according to data from the AFIRE trial.
Elvira Manzano, 12 Nov 2019
Supplementation with omega-3 fatty acids or vitamin D3 for up to 5 years has no effect on kidney function in adults with type 2 diabetes (T2D), the VITAL-DKD* ancillary study has shown.
Jairia Dela Cruz, 4 days ago
Many patients with nonvalvular atrial fibrillation (NVAF) in Thailand use anticoagulants, but the uptake of nonvitamin-K oral anticoagulants remains suboptimal despite showing an upward trend, according to data from the COOL-AF registry presented at the European Society of Cardioloy (ESC) Asia Congress 2019 with APSC and AFC.

Sleep problems implicated in female fertility

05 May 2019

Fecundability may be lower in women who have trouble sleeping at night or have shorter sleep duration, as suggested in a recent study.

The study population comprised 6,873 women aged 21–45 years attempting pregnancy for ≤6 months at enrolment. All of them completed follow-up questionnaires every 8 weeks for up to 12 months to report their pregnancy status.

Researchers analysed the women’s average sleep duration per 24-hour period in the previous month, frequency of trouble sleeping within the last 2 weeks (as measured by the Major Depression Inventory) and shift work patterns in relation to fertility. They used proportional probabilities regression to estimate fecundability.

Compared with women sleeping 8 hours per day, those who slept for <6, 6, 7 and ≥9 hours per day had fecundability ratios (FRs) of 0.89 (95 percent CI, 0.75–1.06), 0.95 (0.86–1.04), 0.99 (0.92–1.06) and 0.96 (0.84–1.10), respectively.

Meanwhile, relative to women who had no trouble sleeping, those who reported having difficulty sleeping <50 percent of the time and >50 percent of the time had FRs of 0.93 (0.88–1.00) and 0.87 (0.79–0.95), respectively.

The associations were slightly stronger among women with higher depressive symptoms and perceived stress levels. Shift work showed no association with fecundability.

Researchers explained that the interaction between stress and sleep may explain the slightly pronounced association between trouble sleeping and fecundability among women with higher depressive symptoms and perceived stress levels.

Stress may temporarily raise the concentration of melatonin. This important sleep-regulating hormone has been reported to have mixed effects on fertility, affecting reproductive hormones differently depending on the cycle phase in which sleep disruption occurs.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Yesterday
Exposure to corticosteroids in patients with autoimmune hepatitis (AIH) appears to contribute to increased risks of cataract, diabetes and bone fractures, a study has found. Notably, the fracture risk is elevated at low doses, while the risk of adverse events overall is dose-dependent and is reversible.
6 days ago
In patients with atrial fibrillation (AF) and stable coronary artery disease (CAD), rivaroxaban monotherapy is noninferior to combination treatment with an antiplatelet therapy in terms of cutting the risk of cardiovascular events and mortality, according to data from the AFIRE trial.
Elvira Manzano, 12 Nov 2019
Supplementation with omega-3 fatty acids or vitamin D3 for up to 5 years has no effect on kidney function in adults with type 2 diabetes (T2D), the VITAL-DKD* ancillary study has shown.
Jairia Dela Cruz, 4 days ago
Many patients with nonvalvular atrial fibrillation (NVAF) in Thailand use anticoagulants, but the uptake of nonvitamin-K oral anticoagulants remains suboptimal despite showing an upward trend, according to data from the COOL-AF registry presented at the European Society of Cardioloy (ESC) Asia Congress 2019 with APSC and AFC.