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Sleep irregularity ups risk of cardiovascular events

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Irregular sleep duration and timing appears to increase the risk of cardiovascular disease (CVD), independent of sleep quantity or quality and traditional CVD risk factors, suggests a study.

A total of 1,992 individuals free of CVD were included in the Multi-Ethnic Study of Atherosclerosis. Participants completed the 7-day wrist actigraphy for sleep assessment from 2010 to 2013 and were prospectively followed through 2016. Sleep regularity was assessed using the standard deviation (SD) of actigraphy-measured sleep duration and sleep-onset timing across 7 days.

The investigators estimated hazard ratios (HRs) for incident CVD according to SD of sleep duration and timing using a Cox proportional hazards model, adjusted for traditional CVD risk factors (including CVD biomarkers) and other sleep-related factors (including average sleep duration). Incident CVD included fatal and nonfatal cardiovascular events.

CVD events occurred in 111 participants during a median follow-up of 4.9 years. The multivariable-adjusted HRs for CVD across categories of sleep duration SD were as follows: 1.00 (reference) for ≤60 min, 1.09 (95 percent confidence interval [CI], 0.62–1.92) for 61–90 min, 1.59 (95 percent CI, 0.91–2.76) for 91–120 min, and 2.14 (95 percent CI, 1.24–3.68) for >120 min (ptrend=0.002).

Likewise, the HRs for CVD were 1.16 (95 percent CI, 0.64–2.13) for 31–60 min, 1.52 (95 percent CI, 0.81–2.88) for 61–90 min, and 2.11 (95 percent CI, 1.13–3.91) for >90 min (ptrend=0.002) compared with participants with a sleep timing SD ≤30 min.

Results were consistent even after exclusion of current shift workers.

“Irregular sleep schedules, characterized by high day-to-day variability in sleep duration or timing, represent possibly milder but much more common and chronic disruption of circadian rhythms in the general population than shift work,” the investigators said.

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Most Read Articles
Roshini Claire Anthony, 6 days ago

For coffee drinkers, drinking filtered coffee may be tied to a lower mortality risk, including cardiovascular disease (CVD)-related mortality, a study from Norway suggested.

Elvira Manzano, 13 Apr 2020
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4 days ago
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