Most Read Articles
Roshini Claire Anthony, 5 days ago

A genotype-guided approach to warfarin dosing may result in fewer dose adjustments in Asian patients, according to a study from Singapore.

10 Aug 2018

Fungal microbiome, also called the mycobiome, appears to be highly variable in patients with well-characterized fungal diseases, a recent study has shown. Moreover, severe asthmatics have the highest fungal loads, along with those receiving steroid and antifungal therapy.

Tristan Manalac, 6 days ago
The risk of complicated appendicitis is lower in children with IgE-mediated allergy, according to a recent study.
21 Jul 2018
Although many patients with atopic dermatitis (AD) use antihistamines, no high-level evidence exists to prove that nonsedating antihistamines reduce itch in patients with AD or provide benefit in controlling AD symptoms, except perhaps sleep and AD comorbidities such as allergic rhinitis, according to a study.

Sleep disturbances up risk of all-cause mortality

13 Jun 2018

Individuals who report sleep disturbances have a significantly higher age-adjusted mortality, according to the UK Biobank study.

“Sleep disturbances were common in this cohort; only one-quarter reported never/rarely having sleep disturbances,” the authors said.

Of the participants, 24.1 percent reported “never/rarely” for the frequency of sleep disturbances, while 47.7 percent and 28.2 percent reported “sometimes” and “usually,” respectively. Risk of all-cause mortality was significantly greater in those who sometimes (hazard ratio [HR], 1.07; 95 percent CI, 1.02–1.12) or usually (HR, 1.27; 1.21–1.34) had sleep disturbances than in those who never/rarely had any.

In addition, risk of cancer mortality was also higher in participants who sometimes (HR, 1.09; 1.02–1.15) or usually (HR, 1.24; 1.16–1.33) had sleep disturbances. Of note, risk of cardiovascular disease (CVD) mortality was also elevated among individuals who usually had sleep disturbances (HR, 1.17; 1.05–1.30).

“Reducing sleep disturbances could have a significant public health impact,” the authors said.

A prospective, population-based cohort study, the UK Biobank was designed to examine risk factors for major diseases of middle and older age. It included 502,642 participants aged 37–73 years (53 percent women) from across the UK, with a mean follow-up time of 6.5 years.

All-cause cancer and CVD mortality were the primary outcomes. Primary exposure was sleep disturbances, based on the questions, “Do you have trouble falling asleep at night or do you wake up in the middle of the night.” Responses were never/rarely, sometimes or usually. Cox proportional hazard models were used adjusting for age, sex, smoking, body mass index and depression.

“Inadequate sleep has been associated with increased prevalence and incidence of a variety of diseases, including diabetes, CVD and cancer,” the authors noted. “Some characteristics of sleep, such as sleep duration, have also been associated with increased mortality risk.”

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Most Read Articles
Roshini Claire Anthony, 5 days ago

A genotype-guided approach to warfarin dosing may result in fewer dose adjustments in Asian patients, according to a study from Singapore.

10 Aug 2018

Fungal microbiome, also called the mycobiome, appears to be highly variable in patients with well-characterized fungal diseases, a recent study has shown. Moreover, severe asthmatics have the highest fungal loads, along with those receiving steroid and antifungal therapy.

Tristan Manalac, 6 days ago
The risk of complicated appendicitis is lower in children with IgE-mediated allergy, according to a recent study.
21 Jul 2018
Although many patients with atopic dermatitis (AD) use antihistamines, no high-level evidence exists to prove that nonsedating antihistamines reduce itch in patients with AD or provide benefit in controlling AD symptoms, except perhaps sleep and AD comorbidities such as allergic rhinitis, according to a study.