Most Read Articles
06 Dec 2018
A strong belief in the necessity of medication is associated with better adherence to oral disease-modifying antirheumatic drugs (DMARDs) or prednisone, while higher self-efficacy correlates with poor adherence, in a diverse cohort of patients with rheumatoid arthritis (RA), suggests a study.
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First-line therapy with the BTK* inhibitor ibrutinib plus the anti-CD20 immunotherapy rituximab confers significant survival advantage over the current gold-standard regimen of fludarabine, cyclophosphamide, and rituximab (FCR) for young, fit patients with treatment-naïve chronic lymphocytic leukaemia (CLL), according to the E1912 trial, a large cooperative group study supported by the US National Cancer Institute.
6 days ago
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Percutaneous coronary intervention (PCI) displays comparable rates of mortality and serious composite outcomes but a higher rate of target-vessel revascularization at 10 years relative to coronary artery bypass grafting (CABG) in patients with significant left main coronary artery (LMCA) disease, reports a study. On the other hand, CABG delivers lower mortality and serious composite outcome rates compared with PCI with drug-eluting stents after 5 years.

Sleep disruptions may worsen negative thinking

08 Jan 2018
Women with sleep disorders may be more than three times as likely to experience infertility as those who sleep well.

Disruptions in sleep negatively affect the top-down, rule-based control of attention to negative stimuli and are correlated with greater difficulty disengaging from negative images and more time looking at emotionally negative images, a recent study has found.

After subjecting 52 community-dwelling adults to a hybrid free-viewing and directed attention task, researchers found that those with shorter habitual sleep duration were significantly more likely to dwell on negative than on neutral stimuli during the free viewing phase of the task (p=0.01). All recruited participants had high levels of transdiagnostic repetitive negative thinking (RNT).

The association was not attenuated by the adjustments for anxious arousal and anhedonic depression symptoms (p=0.01). Moreover, habitual sleep duration was not significantly correlated with the time looking at positive compared with neutral stimuli (p=0.39).

In the engage/disengage part of the task, researchers found that participants with longer sleep onset latency were significantly slower in disengaging from negative than from neutral stimuli even after adjusting for confounders (p=0.01 for both). Sleep onset latency was not associated with time to engage with negative stimuli (p=0.98).

In terms of sleep duration, those with shorter habitual sleep also had slower disengaging from negative than neutral stimuli even after all adjustments (p=0.02 for both). Engaging with negative stimuli was likewise unrelated to habitual sleep duration.

“The pattern of results in this study suggest that individuals with heightened levels of RNT and greater degrees of chronic sleep pressure demonstrate a specific effect on top-down direction of attention,” said researchers.

“Further study is needed to understand how sleep and circadian rhythm disruptions interact with the allocation of attention,” they added.

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Most Read Articles
06 Dec 2018
A strong belief in the necessity of medication is associated with better adherence to oral disease-modifying antirheumatic drugs (DMARDs) or prednisone, while higher self-efficacy correlates with poor adherence, in a diverse cohort of patients with rheumatoid arthritis (RA), suggests a study.
Pearl Toh, 22 hours ago
First-line therapy with the BTK* inhibitor ibrutinib plus the anti-CD20 immunotherapy rituximab confers significant survival advantage over the current gold-standard regimen of fludarabine, cyclophosphamide, and rituximab (FCR) for young, fit patients with treatment-naïve chronic lymphocytic leukaemia (CLL), according to the E1912 trial, a large cooperative group study supported by the US National Cancer Institute.
6 days ago
Low-dose administrations of haloperidol after thoracic surgery does not appear to prevent postoperative delirium, according to a new study.
4 days ago
Percutaneous coronary intervention (PCI) displays comparable rates of mortality and serious composite outcomes but a higher rate of target-vessel revascularization at 10 years relative to coronary artery bypass grafting (CABG) in patients with significant left main coronary artery (LMCA) disease, reports a study. On the other hand, CABG delivers lower mortality and serious composite outcome rates compared with PCI with drug-eluting stents after 5 years.