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Sleep-disordered breathing a red flag for ischaemic stroke recurrence

15 Mar 2019

Sleep-disordered breathing (SDB) is associated with an increased risk of recurrent ischaemic stroke but not mortality, a study has shown.

The study included 842 ischaemic stroke patients (median age, 65 years; 47 percent female) from the BASIC* project. All patients underwent screening for SDB (defined as respiratory event index [REI] score ≥10) with the ApneaLink Plus device, as well as active and passive surveillance for recurrent ischaemic stroke.

Results showed that the median REI score was 14 (interquartile range, 6–26), with more than half of the population (63 percent) having SDB. SDB was associated with male sex, Mexican American ethnicity, lower educational attainment, higher body mass index, nonsmoking status, diabetes mellitus and hypertension.

Among 775 Mexican American and non-Hispanic whites with an index stroke event and complete data, 85 (11 percent) recurrent ischaemic stroke events and 104 (13 percent) deaths occurred over a median follow-up of 591 days.

In fully adjusted cause-specific proportional hazards models, REI was associated with an increased risk of recurrent ischaemic stroke (1-unit higher REI score: hazard ratio [HR], 1.02; 95 percent CI, 1.01–1.03) but not with the risk of mortality alone (HR, 1.00; 0.99–1.02).

According to researchers, SDB could not explain the previously identified higher risk of recurrent stroke in Mexican Americans vs non-Hispanic whites. Nevertheless, the present data support the need for a trial of SDB treatment for recurrent stroke prevention regardless of ethnicity.

*Brain Attack Surveillance in Corpus Christ

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Most Read Articles
Roshini Claire Anthony, 04 Apr 2019

In addition to an intensive weight loss programme, the use of continuous positive airway pressure (CPAP) could improve absolute weight loss in individuals with obesity and obstructive sleep apnoea (OSA), according to a study presented at ENDO 2019.

4 days ago
The ketogenic and Modified Atkin’s diets are effective treatments for children with refractory epilepsy of genetic aetiology, a new study suggests.
5 days ago
Extremely premature neonates who have been exposed to pre-eclampsia in utero are at high risk of developing severe respiratory distress syndrome and severe bronchopulmonary dysplasia, according to a study.
Pearl Toh, 3 days ago
A contraceptive vaginal system (Annovera) releasing a combination of segesterone acetate and ethinyl estradiol (SA/EE) effectively inhibits ovulation up to a year even at low systemic levels of SA, reports a review study presented at ENDO 2019.