Most Read Articles
6 days ago
Regardless of birth weight, being obese at preschool age is associated with a greater risk of elevated blood pressure during early childhood, a recent China study has found. A longer duration of breastfeeding appears to help mitigate such a risk.
Jairia Dela Cruz, 3 days ago
In patients with heart failure with reduced ejection fraction (HFrEF) receiving angiotensin-converting-enzyme (ACE) inhibitors, high dosing confers benefits for the risk of death or hospitalization that are similar to that obtained with lower dosing, according to a systematic review and meta-analysis.
06 Sep 2020
Type 2 diabetes mellitus patients taking proton pump inhibitors (PPIs) are at a higher risk of sustaining hip fractures, a recent study has found.
Audrey Abella, Yesterday
Adults who suffered maltreatment during their childhood are more likely to develop cardiovascular disease (CVD), with stronger associations observed in women, a UK study has shown.

Simplified risk-stratified aspirin protocol safe, effective in patients undergoing joint arthroplasty

10 Aug 2020
For nearly 100 years, aspirin has been a common drug used for pain relief and fever treatment.

A simplified risk stratification protocol used to select patients for twice-daily aspirin therapy for venous thromboembolism (VTE) prophylaxis has been shown to be safe and effective in those undergoing total joint replacement (TJR), reports a recent study.

Furthermore, surgical site infections and rates of return to operating room appear to be lower when compared to universal warfarin therapy.

The authors carried out a retrospective cohort study to compare 30-day postoperative outcomes 6 months before and after the implementation of the aspirin protocol (1 January 2015) in patients undergoing TJR.

The protocol group included patients who used aspirin 325 mg twice daily or warfarin if deemed high thrombotic risk or aspirin intolerant by the criteria set forth by the aspirin protocol. The control group included those on warfarin for VTE prophylaxis.

A total of 449 patients were included. There was no difference between the control and the protocol groups in the rates of 30-day postoperative bleeding, VTE, death, composite endpoint of VTE and death, and length of stay (pall>0.05).

Thirty-day postoperative surgical site infections (5.8 percent vs 1.2 percent; p=0.02) and return to operating room (3.9 percent vs 0.4 percent; p=0.03) occurred less frequently in the protocol group compared with the control group.

In a 2016 study by Huang and his team, results showed that aspirin is safer than warfarin and just as effective for VTE prophylaxis following TJR, even in patients at increased VTE risk. [J Arthroplasty 2016;doi:10.1016/j.arth.2016.02.074]

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Most Read Articles
6 days ago
Regardless of birth weight, being obese at preschool age is associated with a greater risk of elevated blood pressure during early childhood, a recent China study has found. A longer duration of breastfeeding appears to help mitigate such a risk.
Jairia Dela Cruz, 3 days ago
In patients with heart failure with reduced ejection fraction (HFrEF) receiving angiotensin-converting-enzyme (ACE) inhibitors, high dosing confers benefits for the risk of death or hospitalization that are similar to that obtained with lower dosing, according to a systematic review and meta-analysis.
06 Sep 2020
Type 2 diabetes mellitus patients taking proton pump inhibitors (PPIs) are at a higher risk of sustaining hip fractures, a recent study has found.
Audrey Abella, Yesterday
Adults who suffered maltreatment during their childhood are more likely to develop cardiovascular disease (CVD), with stronger associations observed in women, a UK study has shown.