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Stephen Padilla, 25 Jul 2019
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17 Oct 2019
Use of direct acting antivirals (DAAs) to treat hepatitis C virus (HCV) infection is feasible during pregnancy, as these drugs are highly effective and treatment duration is relatively short, according to a study. In addition, DAA treatment helps improve maternal health and prevent vertical transmission.
Roshini Claire Anthony, 2 days ago

The addition of pertuzumab to a trastuzumab-docetaxel regimen in the neoadjuvant setting improved total pathological complete response (tpCR) rates in Asian women with early or locally advanced ERBB2-positive breast cancer, according to the phase III PEONY trial from China.

Pearl Toh, 09 Sep 2019
Use of menopausal hormone therapy (MHT) was associated with a significantly increased risk of invasive breast cancer, which became progressively greater with longer duration of use, a meta-analysis of worldwide prospective epidemiological studies has shown.

Similar cancer incidence in RA patients treated with tocilizumab or TNF inhibitors

Roshini Claire Anthony
27 Jun 2018

Patients with rheumatoid arthritis have a similar incidence of cancer regardless of whether they are treated with tocilizumab or tumour necrosis factor (TNF) inhibitors, according to a study presented at EULAR 2018.

“This study found no difference in the risk of malignancy, excluding non-melanoma skin cancer, in patients with rheumatoid arthritis who newly switched to tocilizumab versus TNF inhibitors from a different TNF inhibitor, abatacept, or tofacitinib,” said study lead author Associate Professor Seoyoung C. Kim from Brigham and Women’s Hospital-Harvard Medical School in Boston, Massachusetts, US.

Using data from three US healthcare claims databases from 2010 to 2015, researchers identified patients aged ≥18 years with rheumatoid arthritis who had recently initiated treatment with tocilizumab (n=10,393) and propensity score matched them to patients who had recently initiated treatment with TNF inhibitors (n=26,357) following treatment failure with abatacept, tofacitinib, or a different TNF inhibitor.

Patients were followed-up until treatment discontinuation, outcome incidence, disenrollment, death, or end of study. Over the study period, 118 malignancies developed among patients who initiated tocilizumab and 322 among patients who initiated TNF inhibitors.  

The incidence rate of malignancy ranged from 0.81 to 2.18 per 100 person-years among patients who initiated tocilizumab and 0.98 to 2.16 per 100 person-years among patients who initiated TNF inhibitors. [EULAR 2018, abstract OP0002]

Patients who initiated treatment with tocilizumab had a comparable risk of incident cancer with patients who initiated treatment with TNF inhibitors across the three databases (hazard ratio, 0.92, 95 percent confidence interval, 0.74–1.14).

Analyses according to cancer subtype (pertaining to the 10 most commonly occurring cancers [breast, colorectal, bladder, kidney, lung, thyroid, prostate, and uterine cancer, melanoma, and non-Hodgkin’s lymphoma] as well as leukaemia and human papillomavirus-related cancers) revealed similar results to the main finding.

“Our study is one of a few to investigate head-to-head comparisons of malignancy risk between different types of biologics in rheumatoid arthritis,” said Kim.

“The risk of malignancy among patients with rheumatoid arthritis has been of ongoing interest,” said Professor Robert Landewé, Chairperson of the EULAR 2018 Scientific Programme Committee. “With more biologic treatment options available and earlier initiation of therapy, it is important to understand the risk of malignancies in patients with rheumatoid arthritis,” he said.

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Most Read Articles
Stephen Padilla, 25 Jul 2019
Nonvitamin K antagonist oral anticoagulants (NOACs) appear to confer more clinical benefits to elderly patients with atrial fibrillation (AF) than vitamin K antagonist anticoagulants (VKAs), suggests a study, adding that this is primarily driven by the lower rates of major bleeding.
17 Oct 2019
Use of direct acting antivirals (DAAs) to treat hepatitis C virus (HCV) infection is feasible during pregnancy, as these drugs are highly effective and treatment duration is relatively short, according to a study. In addition, DAA treatment helps improve maternal health and prevent vertical transmission.
Roshini Claire Anthony, 2 days ago

The addition of pertuzumab to a trastuzumab-docetaxel regimen in the neoadjuvant setting improved total pathological complete response (tpCR) rates in Asian women with early or locally advanced ERBB2-positive breast cancer, according to the phase III PEONY trial from China.

Pearl Toh, 09 Sep 2019
Use of menopausal hormone therapy (MHT) was associated with a significantly increased risk of invasive breast cancer, which became progressively greater with longer duration of use, a meta-analysis of worldwide prospective epidemiological studies has shown.