Most Read Articles
2 days ago
The types of bariatric surgery differentially affect the risk of developing acute pancreatitis postoperatively, such that the risk is greater in patients who undergo vertical sleeve gastrectomy vs Roux-en-Y gastric bypass surgery, according to a study. Risk factors include younger age and presence of gallstones.
6 days ago
Elderly adults using hypoglycaemic glucose-lowering drugs, such as insulin and glinides, have an excess risk of hospitalization for serious trauma, a recent study has found.
6 days ago
Rather than the presence or type or urinary incontinence, increasing severity of urinary incontinence correlates with increased depression, anxiety and stress among treatment-seeking women with lower urinary tract symptoms (LUTS), suggests a study.
Roshini Claire Anthony, 4 days ago

Overweight or obese patients taking lorcaserin as an appetite suppressant may have the added benefit of a reduced risk of incident diabetes, according to results of the CAMELLIA-TIMI 61* trial presented at EASD 2018.

Signs of thromboembolic events must be monitored in bevacizumab-treated cancer patients

04 Jan 2018

Thromboembolism is a major cause of death in patients with cancer, which is why clinicians should check for the symptoms of thromboembolic events right from the initial stages of bevacizumab treatment, suggests a recent study.

During the sample period, a total of 6,076 patients developed adverse events. Of these, 233 and 453 developed arterial and venous thromboembolic events, respectively.

Based on logistic analysis, the presence of cancer was found to be a significant predictor for both arterial and venous thromboembolic events. Other risk factors for arterial thromboembolic event included age (≥70 years) and histories of either hypertension or diabetes mellitus.

Median cumulative times of onset were 60 days for arterial thromboembolic event and 80 days for venous thromboembolic event, and were not significantly different by the log-rank test. The chi-square test suggested that the rate of unfavourable outcomes was higher after developing arterial thromboembolic event than after venous thromboembolic event.

The authors used adverse event data recorded in the Japanese Adverse Drug Event Report database between January 2004 and January 2015, and classified these into two groups by age and five groups by cancer type after screening the data using the generic drug name bevacizumab.

The authors also categorized the histories of disorders. Arterial and venous thromboembolic events were classified as “favourable” or “unfavourable” outcomes.

In one study, the combination of bevacizumab plus erythropoietin stimulating agent (ESA) was found to increase the incidence of thromboembolic events compared with either agent alone with chemotherapy. Median time of onset was significantly shorter in the combination group than in the bevacizumab group. Researchers suggested that prior venous thromboembolic event, cardiac disease, obesity, and exogenous hormone use should be considered when using the combination of bevacizumab and ESA. [Am J Clin Oncol 2010;33:36-42]

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Most Read Articles
2 days ago
The types of bariatric surgery differentially affect the risk of developing acute pancreatitis postoperatively, such that the risk is greater in patients who undergo vertical sleeve gastrectomy vs Roux-en-Y gastric bypass surgery, according to a study. Risk factors include younger age and presence of gallstones.
6 days ago
Elderly adults using hypoglycaemic glucose-lowering drugs, such as insulin and glinides, have an excess risk of hospitalization for serious trauma, a recent study has found.
6 days ago
Rather than the presence or type or urinary incontinence, increasing severity of urinary incontinence correlates with increased depression, anxiety and stress among treatment-seeking women with lower urinary tract symptoms (LUTS), suggests a study.
Roshini Claire Anthony, 4 days ago

Overweight or obese patients taking lorcaserin as an appetite suppressant may have the added benefit of a reduced risk of incident diabetes, according to results of the CAMELLIA-TIMI 61* trial presented at EASD 2018.