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Sialorrhoea, dystonia reduce HRQoL in kids with leukoencephalopathy

12 Jul 2018
Chan witnessed the effectiveness of Dejian Mind-Body Intervention (DMBI) from a clinical perspective. Photo source: Shutterstock

Health-related quality of life (HRQoL) is lower in patients with more severe genetically determined leukoencephalopathy, according to a recent study.

Using the Paediatric Quality of Life Inventory (PedsQL), researchers assessed HRQoL in 59 patients diagnosed with genetically determined leukoencephalopathies, of whom 38 were male (mean age 8 years, 10 months) and 21 were female (mean age 9 years, 3 months). T-tests were used to determine differences in HRQoL.

Mean PedsQL scores were significantly lower in patients with at least one severe clinical involvement (52.35±18.40 vs 84.03±9.845; p<0.001). This was also true for the physical (40.73±27.79 vs 87.38±19.99; p<0.001), emotional (64.45±24.14 vs 89.39±7.736; p<0.001) and social (54.24±23.72 vs 80.83±18.55; p=0.01) functioning scores.

In terms of specific clinical features, patients with sialorrhoea had significantly lower mean PedsQL scores (48.18±20.12 vs 61.63±18.90), gastrotomy (41.59±21.54 vs 59.49±19.33) and dystonia (47.5±19.4 vs 67.33±14.80; p<0.05 for all) relative to those without the nonmotor symptom.

Wheelchair use also led to significantly lower PedsQL scores (47.66±18.83 vs 63.00±19.49; p<0.05). All four severe clinical presentations likewise resulted in significantly lower physical functioning scores, while only sialorrhoea was associated with significantly poorer emotional functioning.

“By assessing HRQoL, we have identified areas of concern that can be targeted and prioritized when developing care strategies. Interventions should address these specific concerns regarding physical and social functioning,” said researchers, referring to sialorrhoea, gastrotomy, dystonia and wheelchair use.

“Clinicians should pay particular attention to these features when deciding on supportive treatment strategies,” they added.

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Most Read Articles
4 days ago
Use of statin appears to reduce the risks of osteoporosis, hip fractures and vertebral fracture in patients newly diagnosed with a stroke, suggests a recent study.
07 Oct 2018
Patients using long-acting opioids with immunosuppressive properties are at greater risk of developing serious infections compared with those using the nonimmunosuppressive opioid counterpart, according to a study.
5 days ago
Monitoring of adverse events is lower in ambulatory patients on amiodarone than in those on dofetilide, a recent study has found. Improving the monitoring of such agents may help reduce the risk of morbidity in this population.
Yesterday
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