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Tristan Manalac, 18 Nov 2020
The substitution of isoleucine to leucine at amino acid 97 (I97L) in the core region of the hepatitis B virus (HBV) seems to reduce its potency, decreasing the efficiency of both infection and the synthesis of the virus’ covalently closed circular (ccc) DNA, reports a new study presented at The Liver Meeting Digital Experience by the American Association for the Study of Liver Diseases (AASLD 2020).

Shorter penile implants fit for prostatectomy-induced erectile dysfunction

18 Nov 2020

Patients with erectile dysfunction (ED) due to postradical prostatectomy (PRP) seem to require penile implants with shorter cylinders than ED patients whose primary aetiology is vasculogenic in nature, a recent study has found.

Aside from cylinder size, both patient groups have largely comparable implant needs and procedure outcomes.

The study included 117 patients who received virgin implants for ED; 58 had PRP as an aetiology, while 59 developed ED due to vasculogenic causes. All patients had a minimum follow-up of 6 months. The primary study outcome was cylinder and tip size, while procedural factors, such as complications and fibrosis, were set as secondary endpoints.

Cylinder size differed between the two patient groups. Those who had PRP as their primary ED aetiology received larger cylinders, with an average size of 18.30±2.11 cm, as opposed to vasculogenic ED patients, whose average implant cylinder size was 19.21±1.71 cm (p=0.016).

Other variables were comparable between groups. The type of prosthesis used did not differ between aetiology groups, and neither did the prevalence of cavernosal fibrosis requiring vigorous dilatation. The use of cavernotomes was likewise comparable between groups, as was the occurrence of intraoperative complications.

In addition, the researchers likewise found that postoperative complications such as infections, mechanical failures, and extrusions occurred at similar frequencies between groups. Patients were followed for an average of 67.75 months.

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Most Read Articles
4 days ago
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