Shortened DAPT schedule may reduce negative CV outcomes after stent implantation

Roshini Claire Anthony
27 Mar 2019
Early aspirin cessation may reduce negative CV outcomes after stent implantation
Dr Hirotoshi Watanabe

Switching from dual antiplatelet therapy (DAPT) to clopidogrel monotherapy just one month after stent implantation led to a reduction in bleeding without an increase in ischaemic events, the STOPDAPT-2* trial showed.

“One-month DAPT followed by clopidogrel monotherapy as compared with standard 12-month DAPT reduced the bleeding events and did not increase the ischaemic events,” said study lead author Dr Hirotoshi Watanabe from Kyoto University Graduate School of Medicine, Kyoto, Japan, who presented the findings at ACC.19. “That led to a net clinical benefit for both ischaemic and bleeding outcomes.”

This prospective, randomized, open-label study involved participants who underwent percutaneous coronary intervention with cobalt-chromium everolimus-eluting stents at one of 89 medical centres in Japan. Following stent implantation, patients received aspirin plus a P2Y12 inhibitor** for 1 month followed by clopidogrel 75 mg/day monotherapy up to year 5 (1-month DAPT group; n=1,500, mean age 68.1 years, 79 percent male) or aspirin plus a P2Y12 inhibitor for 1 month followed by clopidogrel 75 mg/day plus aspirin for up to 1 year and then aspirin monotherapy up to year 5 (12-month DAPT group; n=1,509, mean age 69.1 years, 77 percent male).

Patients who required oral anticoagulation therapy or had a history of intracranial haemorrhage were excluded.

At 1 year, patients assigned to 1-month DAPT were less likely to experience ischaemic events than those assigned to 12-month DAPT with regard to a composite of cardiovascular (CV) death, myocardial infarction (MI), definite stent thrombosis, stroke, and TIMI*** minor or major bleeding (2.4 percent vs 3.7 percent, hazard ratio [HR], 0.64, 95 percent confidence interval [CI], 0.42–0.98; p<0.001 [noninferiority] and p=0.04 [superiority]). [ACC.19, abstract 410-14]

These improved outcomes were mainly due to the reduction in major or minor bleeding with the 1-month DAPT regimen compared with the 12-month one (0.4 percent vs 1.5 percent, HR, 0.26, 95 percent CI, 0.11–0.64; p=0.004 for superiority).

The incidence of ischaemic events (composite of CV death, MI, stroke, and stent thrombosis) was not elevated with the 1-month DAPT regimen compared with the 12-month regimen (2.0 percent vs 2.5 percent, HR, 0.79, 95 percent CI, 0.49–1.29; p=0.005 [noninferiority] and p=0.34 [superiority]).

At 1 year, the incidence of BARC# 3 or 5 bleeding was less common in the 1-month vs 12-month DAPT group (0.5 percent vs 1.8 percent; p=0.003), with none of the other outcomes demonstrating superiority of the 1-month DAPT regimen.

The lower risk of the composite of ischaemic and bleeding events among patients on 1-month DAPT was consistent across the various subgroups examined including patients aged 75 years or those with acute coronary syndrome. One exception was the small group of patients with severe chronic kidney disease who appeared to benefit from the 12-month regimen (pinteraction=0.03).

“Standard 12-month DAPT is currently recommended by the guidelines,” said Watanabe. “[However], according to our findings, 1-month DAPT followed by clopidogrel monotherapy could be a good option after drug-eluting stent implantation with an advantage of fewer bleeding events,” he said.

One study limitation was the small number of participants considered at high risk for ischaemic events, said Watanabe. Japanese patients also tend to have a lower risk of ischaemic events than their Western counterparts with coronary artery disease, he said.

 

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