Most Read Articles
15 Jan 2018
Body surface area (BSA) affected by psoriasis can be measured to target diabetes prevention efforts for patients with psoriasis, a recent study suggests.
Pearl Toh, 14 Apr 2018
Taking the oral extract product of the fern Polypodium leucotomos (PLE) on top of the standard topical hydroquinone cream and sunscreen reduces the severity of melasma to a greater extent compared with the standard treatment alone in Asian patients, a pilot study has shown.
Jan Welch, 01 Jun 2011

Sexually transmitted infections (STIs) are common, with rates of many infections increas­ing over the last two decades.1 Community screening studies in the UK have shown a prevalence of about 10% for chlamydial infection2 and (among women screened in an urban setting) 3% for gonorrhoea.3 In women (Figure 1), these potentially serious infections are often asymptomatic, whereas the presence of symptoms such as vaginal discharge generally indicates a less pathogenic (but still potentially debilitating) infection, with an organism such as Candida. STIs are often multiple, and the finding of one infection should prompt consider­ation of testing for others. Many sexual health services now initially provide screening tests for asymptomatic women, but a more comprehensive assessment—comprising detailed history4 and genital examination5—is usually necessary when symptoms are present.

Stephen Padilla, 4 days ago
High use of hydrochlorothiazide (HCTZ) appears to significantly increase the risk of nonmelanoma skin cancer (NMSC), particularly squamous cell carcinoma (SCC), suggests a recent study. Use of other diuretic and antihypertensive medications does not appear to be linked to NMSC.

Short-term systemic corticosteroid therapy may be useful in atopic dermatitis

03 Apr 2018

Optimal delivery or duration of systemic corticosteroids in atopic dermatitis (AD) cannot be established as there is not enough strong evidence in existing literature, suggests a recent study.

Findings from previous reports generally agreed that use of systemic steroids should be limited to short courses as a bridge to steroid-sparing therapies.

Systemic side effects were as follows: osteoporosis, osteonecrosis, Cushing syndrome, adrenal insufficiency, diabetes, glucose intolerance, gastro-oesophageal reflux, gastritis, peptic ulcer disease, weight gain, emotional lability and behavioural changes.

Other side effects included growth suppression in children, glaucoma, cataracts, myopathy, hypertension, dysaesthesia, myalgia, pseudotumour cerebri, hyperlipidaemia, malignancy, thrombosis, skin atrophy, rebound flaring and sleep disturbance.

The investigators searched PubMed, Embase, Scopus, Web of Science and Cochrane Library to systematically review published studies on efficacy and safety of systemic corticosteroid use (oral, intramuscular and intravenous) in AD. Included were systematic reviews, guidelines and treatment reviews of systemic corticosteroid use among patients of all ages with AD (52 reviews and 12 studies).

The study was limited by the incomplete and heterogeneous reporting of baseline clinical severity, corticosteroid delivery and dose, and treatment response across studies, according to the investigators.

In a previous systematic review of published trials of topical corticosteroids (TCS) or topical calcineurin inhibitors (TCIs) treatments in patients <12 years with AD, Siegfried and colleagues found robust data supporting long-term use of TCIs, while data supporting long-term TCS use were limited to low- to mid-potency products. [BMC Pediatr 2016;16:75]

“Our review identifies a lack of information on the safety of commonly prescribed, long-term monotherapy with mid- to high-potency TCS in paediatric AD, and supports standard-of-care maintenance therapy with TCIs and intermittent use of low- to mid-potency TCS for flares,” said Siegfried.

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Most Read Articles
15 Jan 2018
Body surface area (BSA) affected by psoriasis can be measured to target diabetes prevention efforts for patients with psoriasis, a recent study suggests.
Pearl Toh, 14 Apr 2018
Taking the oral extract product of the fern Polypodium leucotomos (PLE) on top of the standard topical hydroquinone cream and sunscreen reduces the severity of melasma to a greater extent compared with the standard treatment alone in Asian patients, a pilot study has shown.
Jan Welch, 01 Jun 2011

Sexually transmitted infections (STIs) are common, with rates of many infections increas­ing over the last two decades.1 Community screening studies in the UK have shown a prevalence of about 10% for chlamydial infection2 and (among women screened in an urban setting) 3% for gonorrhoea.3 In women (Figure 1), these potentially serious infections are often asymptomatic, whereas the presence of symptoms such as vaginal discharge generally indicates a less pathogenic (but still potentially debilitating) infection, with an organism such as Candida. STIs are often multiple, and the finding of one infection should prompt consider­ation of testing for others. Many sexual health services now initially provide screening tests for asymptomatic women, but a more comprehensive assessment—comprising detailed history4 and genital examination5—is usually necessary when symptoms are present.

Stephen Padilla, 4 days ago
High use of hydrochlorothiazide (HCTZ) appears to significantly increase the risk of nonmelanoma skin cancer (NMSC), particularly squamous cell carcinoma (SCC), suggests a recent study. Use of other diuretic and antihypertensive medications does not appear to be linked to NMSC.