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Short sleepers at higher risk of myocardial infarction

11 Sep 2019

Short sleep duration is associated with an increased risk of myocardial infarction (MI), according to prospective observational and Mendelian randomization (MR) analyses.

Sleeping for <6 h was associated with a 20-percent higher multivariable-adjusted risk of incident MI (hazard ratio [HR], 1.20, 95 percent CI, 1.07–1.33) compared with sleeping 6–9 h/night, while long sleep duration (>9 h) correlated with 34-percent higher risk (HR, 1.34, 1.13–1.58). These associations were independent of other sleep traits.

On the other hand, MI risk decreased with healthy sleep duration even among individuals with high genetic liability (HR, 0.82, 0.68–0.998). Moreover, MR consistently showed a causal effect of short sleep duration on MI in CARDIoGRAMplusC4D (HR, 1.19, 1.09–1.29) and in UK Biobank (HR, 1.21, 1.08–1.37).

In this study, the authors examined the associations between sleep duration and incident MI, accounting for joint effects with other sleep traits and genetic risk of coronary artery disease, and assessed causality using MR.

Multivariable-adjusted HRs for MI (5,129 incident cases) were estimated across habitual self-reported short and long sleep duration in 461,347 UK Biobank participants free of relevant cardiovascular disease. Joint effects with sleep disturbance traits and a coronary artery disease genetic risk score were also investigated.

Two-sample MR was performed for short (24 single nucleotide polymorphisms) and continuous (71 single nucleotide polymorphisms) sleep duration with MI (n=43,676 cases/128,199 controls). Results were replicated in the UK Biobank (n=12,111/325421).

“Investigation of sleep extension to prevent MI may be warranted,” the authors said.

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Most Read Articles
18 May 2020
Immobilization or disuse of the forearm leads to impairment in the ability of a protein-rich meal to promote positive muscle amino acid balance, which is aggravated by dietary lipid oversupply, suggests a study. Disuse also lowers postprandial forearm amino acid uptake, but this is not exacerbated under high-fat conditions.
18 May 2020
Glucagon-like peptide-1 receptor agonists (GLP-1RA) are more effective than basal insulin in the management of total (TC) and low-density lipoprotein cholesterol (LDL-C), reveals a recent study.
17 May 2020
Increased coffee consumption among regular drinkers is associated with higher estimated glomerular filtration rate and confers protection against the risk of chronic kidney disease stages G3–G5 and albuminuria, as shown in a study.
Jairia Dela Cruz, 16 May 2020
Excess weight, greater abdominal fat, inflammation and low physical performance can all contribute to insulin resistance in middle-age Singaporean women, and these variables explain why the condition is more common among women of Chinese than Malay and Indian ethnicities, a study has found.