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Short sleepers at higher risk of myocardial infarction

11 Sep 2019

Short sleep duration is associated with an increased risk of myocardial infarction (MI), according to prospective observational and Mendelian randomization (MR) analyses.

Sleeping for <6 h was associated with a 20-percent higher multivariable-adjusted risk of incident MI (hazard ratio [HR], 1.20, 95 percent CI, 1.07–1.33) compared with sleeping 6–9 h/night, while long sleep duration (>9 h) correlated with 34-percent higher risk (HR, 1.34, 1.13–1.58). These associations were independent of other sleep traits.

On the other hand, MI risk decreased with healthy sleep duration even among individuals with high genetic liability (HR, 0.82, 0.68–0.998). Moreover, MR consistently showed a causal effect of short sleep duration on MI in CARDIoGRAMplusC4D (HR, 1.19, 1.09–1.29) and in UK Biobank (HR, 1.21, 1.08–1.37).

In this study, the authors examined the associations between sleep duration and incident MI, accounting for joint effects with other sleep traits and genetic risk of coronary artery disease, and assessed causality using MR.

Multivariable-adjusted HRs for MI (5,129 incident cases) were estimated across habitual self-reported short and long sleep duration in 461,347 UK Biobank participants free of relevant cardiovascular disease. Joint effects with sleep disturbance traits and a coronary artery disease genetic risk score were also investigated.

Two-sample MR was performed for short (24 single nucleotide polymorphisms) and continuous (71 single nucleotide polymorphisms) sleep duration with MI (n=43,676 cases/128,199 controls). Results were replicated in the UK Biobank (n=12,111/325421).

“Investigation of sleep extension to prevent MI may be warranted,” the authors said.

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Most Read Articles
20 Jun 2020
The Lundbeck Neuroscience Symposium was held at Sofitel KL Damansara over 2 days, with extensivediscussions on the management of various mental illnesses. The second day of the symposiumaddressed the topic of schizophrenia management, focusing on treatment goals, the rationale forpartial dopamine D(2) receptor agonism and the use of long-acting injectable (LAI) antipsychotics topromote adherence.
Pearl Toh, 4 days ago
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
3 days ago
Patients with psoriatic arthritis (PsA) often suffer from liver abnormalities, which are associated with higher body mass index (BMI), daily consumption of alcohol, more severe disease, and some therapies, according to a recent study.
Christina Lau, 2 days ago

Pembrolizumab in combination with chemotherapy significantly improves progression-free survival (PFS) vs chemotherapy alone in patients with previously untreated, locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC), results of the KEYNOTE-355 study have shown.