Most Read Articles
27 Mar 2018
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Rachel Soon, 16 Mar 2018

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In patients with rheumatoid arthritis (RA), temporary cessation of methotrexate (MTX) treatment for 2 weeks following influenza vaccination appears to improve the immunogenicity of the vaccine without increasing RA disease activity, according to a study.

Short-course TB treatment improves completion rates in paediatric patients

10 Feb 2018

The use of shorter treatment regimens in children with tuberculosis (TB) infection leads to increased rates of completion and fewer adverse events (AEs) when compared with 9 months of daily isoniazid (9H) treatment, a study has shown.

Researchers reviewed the medical records of 667 children with TB infection (median age 8 years; 50.8 percent female) who received 9H (n=252), 4 months of daily rifampin (4R; n=132) or 3 months of once-weekly isoniazid and rifapentine (3HP; n=283).

The 4R and 9H regimens could be administered by families (self-administered therapy [SAT]) or as directly observed preventive therapy (DOPT). On the other hand, 3HP was always administered under DOPT.

Completion rates were highest with 3HP (96.8 percent) and lowest with 9H under SAT (52.6 percent; odds ratio [OR], 27.4; 95 percent CI, 11.8–63.7). When administered under DOPT, 9H had a completion rate of 89 percent (vs 9H under SAT: OR, 7.11; 3.54–14.28). The rates did not significantly differ between 3HP and 4R under DOPT (OR, 1.12; 0.14–9.09).

On multivariable regression analysis, completion of therapy was associated with the following factors: receipt of medication under DOPT (OR, 5.72; 3.47–9.43), increasing age (OR, 1.09; 1.02–1.17) and the absence of any AE (OR, 1.70; 0.26–0.60).

There were 62 children (9.3 percent) overall with complaints of any AE, which occurred frequently in the 9H group (OR, 2.51; 1.48–4.32). Hepatotoxicity was reported in two (0.9 percent) children in the 9H group in none in the 3HP and 4R groups.

The present data indicate that the 3HP and 4R regimens are well tolerated and associated with significantly higher completion rates compared with 9H, with the effectiveness of these short-course regimens being high in the short-term, researchers said.

“We hope that the coming years will see a shift in TB infection diagnosis to IGRAs to enable treatment to target the children who would receive the most benefit from therapy, and that increased data on 3HP pharmacokinetics and more child-friendly formulations of 3HP will enable this shorter regimen to be used in the most vulnerable paediatric population: infants and young children,” they added.

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Most Read Articles
27 Mar 2018
Combination treatment with hydrocortisone plus fludrocortisone reduces 90-day all-cause mortality in patients with septic shock, a study has found.
Rachel Soon, 16 Mar 2018

Intake of calcium supplements may up the risk of developing sessile serrated adenomas or polyps (SSA/Ps) in the colon, according to a new study.

30 Nov 2017
Fluarex Tetra - Inactivated quadrivalent influenza vaccine (split virion) vaccine (inj) 0.5 mL - GlaxoSmithKline
18 Apr 2018
In patients with rheumatoid arthritis (RA), temporary cessation of methotrexate (MTX) treatment for 2 weeks following influenza vaccination appears to improve the immunogenicity of the vaccine without increasing RA disease activity, according to a study.