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SGLT2 reduces required insulin dose in poorly controlled type 2 diabetes

4 days ago
Patients with type 3c diabetes are more likely to require insulin to help control their blood sugar levels.

Sodium-glucose cotransporter 2 (SGLT2) administration concurrent with the initiation of intensive insulin therapy appears to reduce the required insulin doses in patients with poorly controlled type 2 diabetes (T2D), a new study has found.

Researchers randomized 18 T2D patients to receive basal/bolus insulin titration algorithm (INS) either alone (n=9; mean age 55±13.3 years) or with dapagliflozin 5 mg/day (INS/DAPA; n=9; mean age 46.3±9.02). The main study outcomes were total daily dose of insulin needed to achieve euglycaemia, and energy expenditure (EE) and respiratory quotient (RQ) during fasting and postprandial states.

All patients in the INS/DAPA group achieved euglycaemia. This was significantly greater than that in the INS alone group (100 percent vs 55.6 percent; p=0.04).

Moreover, between post-treatment days 5 and 7, patients who were coadministered dapagliflozin required significantly lower insulin doses, when measured as total insulin dose (1.48±0.32 vs 1.81±0.38 U/kg; p<0.05) and basal/bolus ratio (0.41±0.96 vs 0.47±0.77; p<0.05).

There were no significant between-group differences in terms of postprandial and fasting EE. The same was true for postprandial RQ, though fasting values were significantly higher in the INS/DAPA group (0.78±0.07 vs 0.72±0.05; p<0.05). Changes in body weight, blood pressure and urinary glucose excretion were comparable between groups.

Both treatments were comparably safe. Treatment-emergent adverse events were reported in one patient (11.1 percent) in each group. Nausea was reported in both patients, while the one belonging to the INS/DAPA group also had decreased appetite.

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Most Read Articles
Jairia Dela Cruz, 6 days ago
Use of standard-dose aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) appears to confer protection against the risk of endometrial cancer in overweight and obese women, according to a meta-analysis.
Tristan Manalac, 6 days ago
Less than 15 percent of Singaporean adolescents get the recommended 8–10 hours of sleep on a school night, reports a recent study, noting that such short sleep duration is linked to symptoms of depression, overweight or obesity, and poorer self-rated health.
04 Jan 2019
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6 days ago
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