Most Read Articles
12 Jun 2018
Percutaneous coronary intervention (PCI) is a safe procedure to perform on obese and morbidly obese patients, a recent study has shown.
Roshini Claire Anthony, 08 Jun 2018

Early treatment of superficial venous reflux (varicose veins) with endovenous ablation and compression therapy shortened healing time of venous leg ulcers compared with compression therapy either alone or in addition to delayed ablation, according to the EVRA* trial.

 

Sex steroids affect cardiovascular outcomes in transgender individuals

13 Nov 2017

Sex steroid therapy appears to elevate low-density lipoprotein cholesterol (LDL-C) and triglyceride (TG) levels and reduce high-density lipoprotein cholesterol (HDL-C) levels in female-to-male (FTM) individuals, while oral oestrogens appear to increase TG levels in male-to-female (MTF) individuals, suggests a study with low-quality evidence. Moreover, data on significant patient outcomes are still lacking.

Researchers conducted a comprehensive search of several databases up to 7 April 2015 for studies evaluating the effect of sex steroid use on lipids, myocardial infarction, stroke, venous thromboembolism (VTE) and mortality in transgender individuals. A random-effects model was used to pool weighted mean differences and 95 percent confidence intervals (CIs).

A total of 29 studies with moderate risk of bias met the inclusion criteria. Sex steroid in FTM individuals correlated with statistically significant increases in serum TG levels at 3 to 6 months and at ≥24 months (21.4 mg/dL; 95 percent CI, 0.14 to 42.6) and in LDL-C levels at 12 and ≥24 months (17.8 mg/dL; 3.5 to 32.1). There was a significant reduction in HDL-C levels across all follow-up periods (highest at ≥24 months, −8.5 mg/dL; −13.0 to −3.9).

Serum TG levels were significantly greater in MTF individuals at ≥24 months (31.9 mg/dL; 3.9 to 59.9) without any changes in other parameters. There were few reports of myocardial infarction, stroke, VTE and death events, and these more frequently occurred among MTF individuals.

“Transgender individuals receive cross-sex hormonal therapy to induce desired secondary sexual characteristics despite limited data regarding its effects on cardiovascular health,” according to researchers.

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Most Read Articles
12 Jun 2018
Percutaneous coronary intervention (PCI) is a safe procedure to perform on obese and morbidly obese patients, a recent study has shown.
Roshini Claire Anthony, 08 Jun 2018

Early treatment of superficial venous reflux (varicose veins) with endovenous ablation and compression therapy shortened healing time of venous leg ulcers compared with compression therapy either alone or in addition to delayed ablation, according to the EVRA* trial.